Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
BACKGROUND: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis.
METHODS: We retrospectively analyzed data from two different prospective clinical trials that involved 101 ACS patients who underwent percutaneous coronary intervention (PCI) and assessed the non-culprit sites of PCI lesions using IVUS at baseline and at the follow-up. After PCI, all the patients participated in early phase II comprehensive cardiac rehabilitation. Patients were divided into four groups based on whether the average daily step count, measured using a pedometer, was 7000 steps of more and whether the follow-up LDL-C level was <70 mg/dL. At the time of follow-up, we examined the correlation of changes in the PV with LDL-C and PA.
RESULTS: The baseline characteristics of the four study groups were comparable. At the follow-up, plaque regression in both the achievement group (PA and LDL-C reduction) was higher than that in the other three groups. In addition, plaque reduction independently correlated with increased PA and reduction in LDL-C level.
CONCLUSIONS: Combined therapy of intensive PA and achievement of LDL-C target retarded coronary PV in patients with ACS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Journal of clinical medicine - 9(2020), 5 vom: 22. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nishitani-Yokoyama, Miho [VerfasserIn] |
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| Links: |
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| Themen: |
Achievement of LDL-C target |
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| Anmerkungen: |
Date Revised 28.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jcm9051578 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310379598 |
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| 520 | |a BACKGROUND: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis | ||
| 520 | |a METHODS: We retrospectively analyzed data from two different prospective clinical trials that involved 101 ACS patients who underwent percutaneous coronary intervention (PCI) and assessed the non-culprit sites of PCI lesions using IVUS at baseline and at the follow-up. After PCI, all the patients participated in early phase II comprehensive cardiac rehabilitation. Patients were divided into four groups based on whether the average daily step count, measured using a pedometer, was 7000 steps of more and whether the follow-up LDL-C level was <70 mg/dL. At the time of follow-up, we examined the correlation of changes in the PV with LDL-C and PA | ||
| 520 | |a RESULTS: The baseline characteristics of the four study groups were comparable. At the follow-up, plaque regression in both the achievement group (PA and LDL-C reduction) was higher than that in the other three groups. In addition, plaque reduction independently correlated with increased PA and reduction in LDL-C level | ||
| 520 | |a CONCLUSIONS: Combined therapy of intensive PA and achievement of LDL-C target retarded coronary PV in patients with ACS | ||
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| 650 | 4 | |a acute coronary syndrome | |
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| 650 | 4 | |a coronary plaque regression | |
| 650 | 4 | |a integrated backscatter intravascular ultrasound | |
| 650 | 4 | |a physical activity | |
| 700 | 1 | |a Miyauchi, Katsumi |e verfasserin |4 aut | |
| 700 | 1 | |a Shimada, Kazunori |e verfasserin |4 aut | |
| 700 | 1 | |a Yokoyama, Takayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ouchi, Shohei |e verfasserin |4 aut | |
| 700 | 1 | |a Aikawa, Tatsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Kunimoto, Mitsuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Miki |e verfasserin |4 aut | |
| 700 | 1 | |a Honzawa, Akio |e verfasserin |4 aut | |
| 700 | 1 | |a Okazaki, Shinya |e verfasserin |4 aut | |
| 700 | 1 | |a Tsujita, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Koba, Shinji |e verfasserin |4 aut | |
| 700 | 1 | |a Daida, Hiroyuki |e verfasserin |4 aut | |
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