RORγt-driven TH17 Cell Differentiation Requires Epigenetic Control by the Swi/Snf Chromatin Remodeling Complex

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved..

Epigenetic regulation, including chromatin accessibility and posttranslational modifications of histones, is of importance for T cell lineage decision. TH17 cells play a critical role in protective mucosal immunity and pathogenic multiple autoimmune diseases. The differentiation of TH17 cells is dictated by a master transcription factor, RORγt. However, the epigenetic mechanism that controls TH17 cell differentiation remains poorly understood. Here we show that the Swi/Snf complex is required for TH17-mediated cytokine production both in vitro and in vivo. We demonstrate that RORγt recruits and forms a complex with the Swi/Snf complex to cooperate for the RORγt-mediated epigenetic modifications of target genes, including both permissive and repressive ones for TH17 cell differentiation. Our findings thus highlight the Swi/Snf complex as an essential epigenetic regulator of TH17 cell differentiation and provide a basis for the understanding of how a master transcription factor RORγt collaborates with the Swi/Snf complex to govern epigenetic regulation.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:23

Enthalten in:

iScience - 23(2020), 5 vom: 22. Mai, Seite 101106

Sprache:

Englisch

Beteiligte Personen:

Lee, Sungkyu [VerfasserIn]
Kim, Jieun [VerfasserIn]
Min, Hyungyu [VerfasserIn]
Seong, Rho H [VerfasserIn]

Links:

Volltext

Themen:

Immunity
Journal Article
Molecular Mechanism of Gene Regulation
Transcriptomics

Anmerkungen:

Date Revised 10.01.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1016/j.isci.2020.101106

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM310164710