Humanized Plasminogen Mouse Model to Study Group A Streptococcus Invasive Disease
This chapter presents the methodology to carry out infection of humanized plasminogen mice with Group A Streptococcus (GAS). This model of invasive disease has been widely used within the field to study the virulence of different GAS strains, host-pathogen interactions, the importance of particular virulence factors, and preclinical evaluation of novel treatments and vaccines. The model has shown to be highly reproducible and therefore represents an invaluable tool for GAS research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2136 |
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| Enthalten in: |
Methods in molecular biology (Clifton, N.J.) - 2136(2020) vom: 19., Seite 309-316 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rivera-Hernandez, Tania [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.03.2021 Date Revised 08.03.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-1-0716-0467-0_24 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM310132622 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This chapter presents the methodology to carry out infection of humanized plasminogen mice with Group A Streptococcus (GAS). This model of invasive disease has been widely used within the field to study the virulence of different GAS strains, host-pathogen interactions, the importance of particular virulence factors, and preclinical evaluation of novel treatments and vaccines. The model has shown to be highly reproducible and therefore represents an invaluable tool for GAS research | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bacterial dissemination and survival | |
| 650 | 4 | |a Group A Streptococcus | |
| 650 | 4 | |a Humanized plasminogen mouse | |
| 650 | 4 | |a Invasive disease | |
| 650 | 7 | |a Antigens, Bacterial |2 NLM | |
| 650 | 7 | |a Bacterial Outer Membrane Proteins |2 NLM | |
| 650 | 7 | |a Bacterial Proteins |2 NLM | |
| 650 | 7 | |a Carrier Proteins |2 NLM | |
| 650 | 7 | |a Virulence Factors |2 NLM | |
| 650 | 7 | |a Plasminogen |2 NLM | |
| 650 | 7 | |a 9001-91-6 |2 NLM | |
| 700 | 1 | |a Walker, Mark J |e verfasserin |4 aut | |
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