Novel Therapeutics for the Treatment of Burn Infection

Background: Burn injury continues to be a significant cause of morbidity and death, with infectious complications being the primary cause of death. Patients are susceptible to overwhelming infection secondary to both the physical breakdown of the skin and mucosal barrier and the immune dysfunction that accompanies the inflammatory response to a major burn. With resistance to traditional antibiosis looming as a serious threat to patient outcome, advancement in the treatment of burn infections is imperative. Methods: Between February 15 and March 15, 2020, a search of Pubmed and clinicaltrials.gov was performed using search terms such as "burn immunotherapy," "therapeutic microorganisms in burn," "burn infection clinical trials," and applicable variations. Results: Topical antimicrobial drugs continue to be standard of care for burn wound injuries, but personalized and molecular treatments that rely on immune manipulation of the host show great promise. We discuss novel therapeutics for the treatment of burn infection: Probiotics and therapeutic microorganisms, immune modulators, tailored monoclonal antibodies, and extracellular vesicles and proteins. Conclusions: The treatment strategies discussed employ manipulation of structure and function in host immune cells and pathogen virulence for improved outcomes in burn infection.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:22

Enthalten in:

Surgical infections - 22(2021), 1 vom: 01. Feb., Seite 113-120

Sprache:

Englisch

Beteiligte Personen:

Salyer, Christen E [VerfasserIn]
Bomholt, Christina [VerfasserIn]
Beckmann, Nadine [VerfasserIn]
Bergmann, Christian B [VerfasserIn]
Plattner, Courtney A [VerfasserIn]
Caldwell, Charles C [VerfasserIn]

Links:

Volltext

Themen:

Burn injury
Immune modulation
Infection
Journal Article
Microvesicles
Probiotics

Anmerkungen:

Date Completed 24.11.2021

Date Revised 24.11.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1089/sur.2020.104

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM31012185X