Autoinflammatory Mechanisms in Crystal-Induced Arthritis

Copyright © 2020 Oliviero, Bindoli, Scanu, Feist, Doria, Galozzi and Sfriso..

Crystal-induced arthritides have been classified as "type-1 autoinflammatory diseases" for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term "auto" refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:7

Enthalten in:

Frontiers in medicine - 7(2020) vom: 02., Seite 166

Sprache:

Englisch

Beteiligte Personen:

Oliviero, Francesca [VerfasserIn]
Bindoli, Sara [VerfasserIn]
Scanu, Anna [VerfasserIn]
Feist, Eugen [VerfasserIn]
Doria, Andrea [VerfasserIn]
Galozzi, Paola [VerfasserIn]
Sfriso, Paolo [VerfasserIn]

Links:

Volltext

Themen:

Autoinflammatory disease
Crystal-induced arthritis
Inflammasome
Interleukin-1
Interleukin-1 receptor antagonist
Journal Article
Review

Anmerkungen:

Date Revised 28.09.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.3389/fmed.2020.00166

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM310088844