ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY

OBJECTIVE: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil.

METHODS: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemoglobin levels (Hb), drain output, transfusion rates, and thromboembolic events were measured.

RESULTS: Among the patients included in this study, 82 cases received TXA. Blood transfusion occurred in 3 cases of the TXA group (3.7%), and in 27 control group cases (29.7%; p < 0.001). The average Hb decrease was 2.7 g/dl (± 1.39) and the median drain output was 270 mL in the TXA group. In the control group, the values were 3.41 g/dl (± 1.34; p < 0.001) and 460 mL (p < 0.001), respectively. Thromboembolic events occurred in 2 TXA group cases (2.4%) and in 3 control group cases (3.3%; p > 0.999).

CONCLUSION: TXA was effective in reducing blood transfusion rates, Hb decrease, and drain output on the 1st postoperative day without increasing thromboembolic events. Level of evidence III, Retrospective comparative study.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:28

Enthalten in:

Acta ortopedica brasileira - 28(2020), 2 vom: 24. März, Seite 74-77

Sprache:

Englisch

Beteiligte Personen:

Leite, Chilan Bou Ghosson [VerfasserIn]
Ranzoni, Lucas Verissimo [VerfasserIn]
Giglio, Pedro Nogueira [VerfasserIn]
Bonadio, Marcelo Batista [VerfasserIn]
Melo, Lucas DA Ponte [VerfasserIn]
Demange, Marco Kawamura [VerfasserIn]
Gobbi, Riccardo Gomes [VerfasserIn]

Links:

Volltext

Themen:

Blood Transfusion
Journal Article
Knee Replacement Arthroplasty
Tranexamic Acid

Anmerkungen:

Date Revised 14.04.2022

published: Print

Citation Status PubMed-not-MEDLINE

doi:

10.1590/1413-785220202802228410

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM310082021