ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY
OBJECTIVE: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil.
METHODS: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemoglobin levels (Hb), drain output, transfusion rates, and thromboembolic events were measured.
RESULTS: Among the patients included in this study, 82 cases received TXA. Blood transfusion occurred in 3 cases of the TXA group (3.7%), and in 27 control group cases (29.7%; p < 0.001). The average Hb decrease was 2.7 g/dl (± 1.39) and the median drain output was 270 mL in the TXA group. In the control group, the values were 3.41 g/dl (± 1.34; p < 0.001) and 460 mL (p < 0.001), respectively. Thromboembolic events occurred in 2 TXA group cases (2.4%) and in 3 control group cases (3.3%; p > 0.999).
CONCLUSION: TXA was effective in reducing blood transfusion rates, Hb decrease, and drain output on the 1st postoperative day without increasing thromboembolic events. Level of evidence III, Retrospective comparative study.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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Enthalten in: |
Acta ortopedica brasileira - 28(2020), 2 vom: 24. März, Seite 74-77 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Leite, Chilan Bou Ghosson [VerfasserIn] |
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Links: |
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Themen: |
Blood Transfusion |
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Anmerkungen: |
Date Revised 14.04.2022 published: Print Citation Status PubMed-not-MEDLINE |
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doi: |
10.1590/1413-785220202802228410 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM310082021 |
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520 | |a OBJECTIVE: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil | ||
520 | |a METHODS: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemoglobin levels (Hb), drain output, transfusion rates, and thromboembolic events were measured | ||
520 | |a RESULTS: Among the patients included in this study, 82 cases received TXA. Blood transfusion occurred in 3 cases of the TXA group (3.7%), and in 27 control group cases (29.7%; p < 0.001). The average Hb decrease was 2.7 g/dl (± 1.39) and the median drain output was 270 mL in the TXA group. In the control group, the values were 3.41 g/dl (± 1.34; p < 0.001) and 460 mL (p < 0.001), respectively. Thromboembolic events occurred in 2 TXA group cases (2.4%) and in 3 control group cases (3.3%; p > 0.999) | ||
520 | |a CONCLUSION: TXA was effective in reducing blood transfusion rates, Hb decrease, and drain output on the 1st postoperative day without increasing thromboembolic events. Level of evidence III, Retrospective comparative study | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Blood Transfusion | |
650 | 4 | |a Knee Replacement Arthroplasty | |
650 | 4 | |a Tranexamic Acid | |
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700 | 1 | |a Giglio, Pedro Nogueira |e verfasserin |4 aut | |
700 | 1 | |a Bonadio, Marcelo Batista |e verfasserin |4 aut | |
700 | 1 | |a Melo, Lucas DA Ponte |e verfasserin |4 aut | |
700 | 1 | |a Demange, Marco Kawamura |e verfasserin |4 aut | |
700 | 1 | |a Gobbi, Riccardo Gomes |e verfasserin |4 aut | |
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