Poloxamer modified florfenicol instant microparticles for improved oral bioavailability

Copyright © 2020 Elsevier B.V. All rights reserved..

Surfactants can improve the hydrophobicity of poorly water-soluble drugs and increase the stability of microparticles by reducing surface tension. This study describes that surfactant-engineered florfenicol instant microparticles (FIMs) increase bioavailability through a micellar solubilization mechanism. The FIMs were prepared by a modified emulsification method, and the optimal prescription was obtained by a combination of single factor investigation and response surface methodology. The microparticles prepared in this study reduce the polymer materials while increasing the drug content. FIM has a smaller particle size and modification of poloxamer, resulting in better solubility and higher bioavailability. The in vitro solubility of FIM is 1.43 times higher than that of the bulk drug, and the dissolution equilibrium can be achieved in 10 minutes. Compared with florfenicol, FIM showed a decrease in Tmax in the plasma concentration curve, with a peak concentration of 1.43 times and an area of 1.41 times. Considering the advantages of in vitro/in vivo performance and ease of preparation, FIMs may have great application prospects in pharmacy research.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:193

Enthalten in:

Colloids and surfaces. B, Biointerfaces - 193(2020) vom: 15. Sept., Seite 111078

Sprache:

Englisch

Beteiligte Personen:

Zhang, Wei [VerfasserIn]
Liu, Chun-Ping [VerfasserIn]
Chen, Shi-Qi [VerfasserIn]
Liu, Meng-Jiao [VerfasserIn]
Zhang, Li [VerfasserIn]
Lin, Shi-Yu [VerfasserIn]
Shu, Gang [VerfasserIn]
Yuan, Zhi-Xiang [VerfasserIn]
Lin, Ju-Chun [VerfasserIn]
Peng, Guang-Neng [VerfasserIn]
Zhong, Zhi-Jun [VerfasserIn]
Yin, Li-Zi [VerfasserIn]
Zhao, Lin [VerfasserIn]
Fu, Hua-Lin [VerfasserIn]

Links:

Volltext

Themen:

106392-12-5
9J97307Y1H
Bioavailability
FLQ7571NPM
Florfenicol
Journal Article
Microparticle
Poloxamer
Surfactant
Thiamphenicol

Anmerkungen:

Date Completed 01.04.2021

Date Revised 01.04.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.colsurfb.2020.111078

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM310051630