Study the association of transmembrane serine protease 6 gene polymorphisms with iron deficiency status in Saudi Arabia

Copyright © 2020 Elsevier B.V. All rights reserved..

BACKGROUND: Intheclinical setting, iron deficiencyanaemia(IDA) represents a majorglobalhealthconcern. This health condition is reported in 30% of non-pregnant women, 42% of pregnant women (aged 15-50 years), 12.7% of men (15 years or older) and in 47% of preschool children (aged 0 to 5 years). Several genetic polymorphisms associated with iron status havebeen identified by using genome-wide association studies.

AIM: This study aimed to identify the functional polymorphismsrs855791 and rs2111833 in the transmembrane serine protease 6 (TMPRSS6) gene in female university students with IDA inthe Kingdom of Saudi Arabia.

METHODS: About 108 female students, aged from 18 to 25 years, were randomly selected and included to this study. Fifty-eightparticipants were iron deficient, and fifty participants were healthy. Blood samples were collected from all participants andassessed based on theirhaematologicaland biochemical iron status indices. Genotyping was carried out byusing PCR.

RESULTS: The genotype distribution oftheTMPRSS6rs855791 region in female studentsfromTabuk University,northern Saudi Arabia,was0% (CC), 77.6% (CT) and 22.4% (TT) in the iron-deficient students compared to 2% (CC), 96% (CT) and 2% (TT) in the healthy students,indicating significant differences in the allelic distribution betweentheiron-deficient group andthehealthy group. The genotype distribution of theTMPRSS6rs2111833 polymorphism was 8.6% (GG), 89.7% (GA) and 1.7% (AA) inthe iron-deficient students compared to 6% (GG), 92% (GA) and 2% (AA) in the healthy students,respectively,showing no differences between the iron-deficient group andthehealthy group in allelic distribution.

CONCLUSION: Our data demonstrated that theTMPRSS6 polymorphism rs855791 is significantly associated with decreased iron status, whereasTMPRSS6 polymorphismrs2111833 is not linked with iron deficiency status in female university students innorthern Saudi Arabia.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:751

Enthalten in:

Gene - 751(2020) vom: 15. Aug., Seite 144767

Sprache:

Englisch

Beteiligte Personen:

Al-Amer, Osama [VerfasserIn]
Hawasawi, Yousef [VerfasserIn]
Oyouni, Atif Abdulwahab A [VerfasserIn]
Alshehri, Mohammed [VerfasserIn]
Alasmari, Abdulrahman [VerfasserIn]
Alzahrani, Othman [VerfasserIn]
Aljohani, Saad Ali S [VerfasserIn]

Links:

Volltext

Themen:

EC 3.4.21.-
Iron deficiency anaemia (IDA)
Journal Article
Membrane Proteins
SNP genotype and female students
Serine Endopeptidases
TMPRSS6
TMPRSS6 protein, human

Anmerkungen:

Date Completed 22.06.2020

Date Revised 04.12.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.gene.2020.144767

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM310048362