Zinc as a Therapeutic Agent in Bone Regeneration
Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
|---|---|
| Enthalten in: |
Materials (Basel, Switzerland) - 13(2020), 10 vom: 12. Mai |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
O'Connor, J Patrick [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Bone biology |
|---|
| Anmerkungen: |
Date Revised 11.11.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3390/ma13102211 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM309912695 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM309912695 | ||
| 003 | DE-627 | ||
| 005 | 20231225134944.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ma13102211 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1033.xml |
| 035 | |a (DE-627)NLM309912695 | ||
| 035 | |a (NLM)32408474 | ||
| 035 | |a (PII)E2211 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a O'Connor, J Patrick |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Zinc as a Therapeutic Agent in Bone Regeneration |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 11.11.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a bone biology | |
| 650 | 4 | |a bone healing | |
| 650 | 4 | |a bone regeneration | |
| 650 | 4 | |a chondrocytes | |
| 650 | 4 | |a osteoblasts | |
| 650 | 4 | |a osteoclasts | |
| 650 | 4 | |a osteogenesis | |
| 650 | 4 | |a therapeutics | |
| 650 | 4 | |a zinc | |
| 700 | 1 | |a Kanjilal, Deboleena |e verfasserin |4 aut | |
| 700 | 1 | |a Teitelbaum, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Sheldon S |e verfasserin |4 aut | |
| 700 | 1 | |a Cottrell, Jessica A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Materials (Basel, Switzerland) |d 2009 |g 13(2020), 10 vom: 12. Mai |w (DE-627)NLM208535349 |x 1996-1944 |7 nnns |
| 773 | 1 | 8 | |g volume:13 |g year:2020 |g number:10 |g day:12 |g month:05 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ma13102211 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 13 |j 2020 |e 10 |b 12 |c 05 | ||