Thyroid Function Modulates Lung Fluid and Alveolar Viscoelasticity in Mechanically Ventilated Rat

Copyright © 2020 Elsevier Inc. All rights reserved..

BACKGROUND: Mechanical ventilation (MV) is life saving; yet it may induce severe lung injury and lead to multisystem organ failure and death. Thyroid hormones (THs) promote alveolar fluid clearance and alleviates hypoxia-induced lung injury. Given that the mechanism involved in hypoxia-induced lung injury is different from that of ventilator-induced lung injury, we examined the effects of thyroid function on lung extravascular fluid (LF), aquaporin 5 (AQP 5) expression, and alveolar viscoelasticity (AVE) in mechanically ventilated rat.

METHODS: Hypothyroid (hypo) and hyperthyroid (hyper) animals were generated by administration of metimazole and L-thyroxine, respectively. Lung injury was induced by high-tidal volume MV. The LF was estimated by lung wet weight-to-dry weight ratio assessment. Expression of AQP 5 was evaluated by western blotting and in situ immunohistochemistry. The AVE was judged by elastic lung pressure/volume curve recording.

RESULTS: Injurious MV significantly reduced lung AQP 5 expression and altered LF and AVE in a thyroid function-dependent manner. Regardless of animals' ventilation mode, hyper state caused significant reductions in LF and lung AQP 5 protein. It also improved AVE irrespective of animals' ventilation mode. The effects of hypo condition on LF, AQP 5 expression, and AVE were in contrast to that of hyper state.

CONCLUSIONS: These data indicate that thyroid function has profound effects on LF, AQP 5, and AVE in mechanically ventilated lungs. Given that the effects of thyroidal status were as prominent as that of injurious MV, we suggest that thyroid function should be considered when patients are to be subjected to MV.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:253

Enthalten in:

The Journal of surgical research - 253(2020) vom: 15. Sept., Seite 272-279

Sprache:

Englisch

Beteiligte Personen:

Owji, Mohammad S [VerfasserIn]
Varedi, Masoumeh [VerfasserIn]
Naghibalhossaini, Fakhraddin [VerfasserIn]
Pajouhi, Nasser [VerfasserIn]

Links:

Volltext

Themen:

554Z48XN5E
AQP 5
Antithyroid Agents
Aqp5 protein, rat
Aquaporin 5
Journal Article
Lung fluid and compliance
Methimazole
Q51BO43MG4
Research Support, Non-U.S. Gov't
Thyroid Hormones
Thyroid hormone
Thyroxine
Ventilator-induced lung injury

Anmerkungen:

Date Completed 27.10.2020

Date Revised 27.10.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.jss.2020.03.060

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309858216