The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer
Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the present study was to examine the relationship between Eastern Cooperative Oncology Group-Performance status (ECOG-PS), modified Glasgow Prognostic Score (mGPS), Body Mass Index/ Weight Loss grade (BMI/WL grade), and Computerised Tomography (CT)-derived body composition measurement and physical function in patients with advanced cancer. Nine sites contributed prospective data on patient demographics, ECOG-PS, mGPS, physical function tests, and CT-derived body composition. Categorical variables were analysed using χ2 test for linear-by-linear association, or χ2 test for 2-by-2 tables. Associations were analysed using binary logistic regression. A total of 523 cancer patients (266 males, 257 females) were included in the final analysis and most had metastatic disease (83.2%). The median overall survival was 5.6 months. On multivariate binary logistic regression analysis, a high ECOG-PS remained independently associated with a low skeletal muscle index (p < 0.001), low skeletal muscle density (p < 0.05), and timed up and go test failure (p < 0.001). A high mGPS remained independently associated with a low skeletal muscle density (p < 0.05) and hand grip strength test failure (p < 0.01). A high BMI/WL grade remained independently associated with a low subcutaneous fat index (p < 0.05), low visceral obesity (p < 0.01), and low skeletal muscle density (p < 0.05). In conclusion, a high ECOG-PS and a high mGPS as outlined in the ECOG-PS/mGPS framework were consistently associated with poorer body composition and physical function in patients with advanced cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Cancers - 12(2020), 5 vom: 08. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dolan, Ross D [VerfasserIn] |
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| Links: |
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| Themen: |
Advanced cancer |
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| Anmerkungen: |
Date Revised 16.02.2022 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/cancers12051187 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309801575 |
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| 100 | 1 | |a Dolan, Ross D |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Relationship between ECOG-PS, mGPS, BMI/WL Grade and Body Composition and Physical Function in Patients with Advanced Cancer |
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| 520 | |a Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the present study was to examine the relationship between Eastern Cooperative Oncology Group-Performance status (ECOG-PS), modified Glasgow Prognostic Score (mGPS), Body Mass Index/ Weight Loss grade (BMI/WL grade), and Computerised Tomography (CT)-derived body composition measurement and physical function in patients with advanced cancer. Nine sites contributed prospective data on patient demographics, ECOG-PS, mGPS, physical function tests, and CT-derived body composition. Categorical variables were analysed using χ2 test for linear-by-linear association, or χ2 test for 2-by-2 tables. Associations were analysed using binary logistic regression. A total of 523 cancer patients (266 males, 257 females) were included in the final analysis and most had metastatic disease (83.2%). The median overall survival was 5.6 months. On multivariate binary logistic regression analysis, a high ECOG-PS remained independently associated with a low skeletal muscle index (p < 0.001), low skeletal muscle density (p < 0.05), and timed up and go test failure (p < 0.001). A high mGPS remained independently associated with a low skeletal muscle density (p < 0.05) and hand grip strength test failure (p < 0.01). A high BMI/WL grade remained independently associated with a low subcutaneous fat index (p < 0.05), low visceral obesity (p < 0.01), and low skeletal muscle density (p < 0.05). In conclusion, a high ECOG-PS and a high mGPS as outlined in the ECOG-PS/mGPS framework were consistently associated with poorer body composition and physical function in patients with advanced cancer | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Glasgow prognostic score | |
| 650 | 4 | |a advanced cancer | |
| 650 | 4 | |a body composition | |
| 650 | 4 | |a computed tomography | |
| 650 | 4 | |a physical function testing | |
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| 700 | 1 | |a Simmons, Claribel Pl |e verfasserin |4 aut | |
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| 700 | 1 | |a Sim, Wei Mj |e verfasserin |4 aut | |
| 700 | 1 | |a Fallon, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Power, Derek G |e verfasserin |4 aut | |
| 700 | 1 | |a Wilcock, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Maddocks, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Bennett, Michael I |e verfasserin |4 aut | |
| 700 | 1 | |a Usborne, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Laird, Barry J |e verfasserin |4 aut | |
| 700 | 1 | |a McMillan, Donald C |e verfasserin |4 aut | |
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