Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats
Tangeretin (TAN) exhibited antilipogenic, antidiabetic, and lipid-lowering effects. However, the lipid biomarkers and the underlying mechanisms for antiobesity and cholesterol-lowering effects of TAN have not been sufficiently investigated. Herein, we integrated biochemical analysis with lipidomics to elucidate its efficacy and mechanisms in high-fat diet-fed rats. TAN at supplementation levels of 0.04 and 0.08% not only significantly decreased body weight gain, serum total cholesterol, and low-density lipoprotein cholesterol levels but also ameliorated hepatic steatosis. These beneficial effects were associated with the declining levels of fatty acids, diacylglycerols (DGs), triacylglycerols, ceramides, and cholesteryl esters by hepatic lipidomics analysis, which were attributed to downregulating lipogenesis-related genes and upregulating lipid oxidation- and bile acid biosynthesis-related genes. Additionally, 21 lipids were identified as potential lipid biomarkers, such as DGs and phosphatidylethanolamines. These findings indicated that the modulation of lipid homeostasis might be the key pathways for the mechanisms of TAN in the antiobesity and cholesterol-lowering effects.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
---|---|
Enthalten in: |
Journal of agricultural and food chemistry - 68(2020), 22 vom: 03. Juni, Seite 6142-6153 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Feng, Konglong [VerfasserIn] |
---|
Links: |
---|
Themen: |
97C5T2UQ7J |
---|
Anmerkungen: |
Date Completed 08.01.2021 Date Revised 08.01.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1021/acs.jafc.0c01778 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM309778433 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM309778433 | ||
003 | DE-627 | ||
005 | 20231225134648.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1021/acs.jafc.0c01778 |2 doi | |
028 | 5 | 2 | |a pubmed24n1032.xml |
035 | |a (DE-627)NLM309778433 | ||
035 | |a (NLM)32394707 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Feng, Konglong |e verfasserin |4 aut | |
245 | 1 | 0 | |a Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 08.01.2021 | ||
500 | |a Date Revised 08.01.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Tangeretin (TAN) exhibited antilipogenic, antidiabetic, and lipid-lowering effects. However, the lipid biomarkers and the underlying mechanisms for antiobesity and cholesterol-lowering effects of TAN have not been sufficiently investigated. Herein, we integrated biochemical analysis with lipidomics to elucidate its efficacy and mechanisms in high-fat diet-fed rats. TAN at supplementation levels of 0.04 and 0.08% not only significantly decreased body weight gain, serum total cholesterol, and low-density lipoprotein cholesterol levels but also ameliorated hepatic steatosis. These beneficial effects were associated with the declining levels of fatty acids, diacylglycerols (DGs), triacylglycerols, ceramides, and cholesteryl esters by hepatic lipidomics analysis, which were attributed to downregulating lipogenesis-related genes and upregulating lipid oxidation- and bile acid biosynthesis-related genes. Additionally, 21 lipids were identified as potential lipid biomarkers, such as DGs and phosphatidylethanolamines. These findings indicated that the modulation of lipid homeostasis might be the key pathways for the mechanisms of TAN in the antiobesity and cholesterol-lowering effects | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a antiobesity | |
650 | 4 | |a cholesterol-lowering | |
650 | 4 | |a diacyglycerols | |
650 | 4 | |a lipidomics | |
650 | 4 | |a tangeretin | |
650 | 7 | |a Anti-Obesity Agents |2 NLM | |
650 | 7 | |a Fatty Acids |2 NLM | |
650 | 7 | |a Flavones |2 NLM | |
650 | 7 | |a Triglycerides |2 NLM | |
650 | 7 | |a Cholesterol |2 NLM | |
650 | 7 | |a 97C5T2UQ7J |2 NLM | |
650 | 7 | |a tangeretin |2 NLM | |
650 | 7 | |a I4TLA1DLX6 |2 NLM | |
700 | 1 | |a Lan, Yaqi |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Xiaoai |e verfasserin |4 aut | |
700 | 1 | |a Li, Jun |e verfasserin |4 aut | |
700 | 1 | |a Chen, Tong |e verfasserin |4 aut | |
700 | 1 | |a Huang, Qingrong |e verfasserin |4 aut | |
700 | 1 | |a Ho, Chi-Tang |e verfasserin |4 aut | |
700 | 1 | |a Chen, Yunjiao |e verfasserin |4 aut | |
700 | 1 | |a Cao, Yong |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of agricultural and food chemistry |d 1967 |g 68(2020), 22 vom: 03. Juni, Seite 6142-6153 |w (DE-627)NLM000005665 |x 1520-5118 |7 nnns |
773 | 1 | 8 | |g volume:68 |g year:2020 |g number:22 |g day:03 |g month:06 |g pages:6142-6153 |
856 | 4 | 0 | |u http://dx.doi.org/10.1021/acs.jafc.0c01778 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 68 |j 2020 |e 22 |b 03 |c 06 |h 6142-6153 |