Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats

Tangeretin (TAN) exhibited antilipogenic, antidiabetic, and lipid-lowering effects. However, the lipid biomarkers and the underlying mechanisms for antiobesity and cholesterol-lowering effects of TAN have not been sufficiently investigated. Herein, we integrated biochemical analysis with lipidomics to elucidate its efficacy and mechanisms in high-fat diet-fed rats. TAN at supplementation levels of 0.04 and 0.08% not only significantly decreased body weight gain, serum total cholesterol, and low-density lipoprotein cholesterol levels but also ameliorated hepatic steatosis. These beneficial effects were associated with the declining levels of fatty acids, diacylglycerols (DGs), triacylglycerols, ceramides, and cholesteryl esters by hepatic lipidomics analysis, which were attributed to downregulating lipogenesis-related genes and upregulating lipid oxidation- and bile acid biosynthesis-related genes. Additionally, 21 lipids were identified as potential lipid biomarkers, such as DGs and phosphatidylethanolamines. These findings indicated that the modulation of lipid homeostasis might be the key pathways for the mechanisms of TAN in the antiobesity and cholesterol-lowering effects.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:68

Enthalten in:

Journal of agricultural and food chemistry - 68(2020), 22 vom: 03. Juni, Seite 6142-6153

Sprache:

Englisch

Beteiligte Personen:

Feng, Konglong [VerfasserIn]
Lan, Yaqi [VerfasserIn]
Zhu, Xiaoai [VerfasserIn]
Li, Jun [VerfasserIn]
Chen, Tong [VerfasserIn]
Huang, Qingrong [VerfasserIn]
Ho, Chi-Tang [VerfasserIn]
Chen, Yunjiao [VerfasserIn]
Cao, Yong [VerfasserIn]

Links:

Volltext

Themen:

97C5T2UQ7J
Anti-Obesity Agents
Antiobesity
Cholesterol
Cholesterol-lowering
Diacyglycerols
Fatty Acids
Flavones
I4TLA1DLX6
Journal Article
Lipidomics
Tangeretin
Triglycerides

Anmerkungen:

Date Completed 08.01.2021

Date Revised 08.01.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1021/acs.jafc.0c01778

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309778433