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Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients

Effective strategy to mitigate the ongoing pandemic of 2019 novel coronavirus (COVID-19) require a comprehensive understanding of humoral responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the emerging virus causing COVID-19. The dynamic profile of viral replication and shedding along with viral antigen specific antibody responses among COVID-19 patients started to be reported but there is no consensus on their patterns. Here, we conducted a serial investigation on 21 individuals infected with SARS-CoV-2 in two medical centres from Jiangsu Province, including 11 non-severe COVID-19 patients, and 5 severe COVID-19 patients and 5 asymptomatic carriers based on nucleic acid test and clinical symptoms. The longitudinal swab samples and sera were collected from these people for viral RNA testing and antibody responses, respectively. Our data revealed different pattern of seroconversion among these groups. All 11 non-severe COVID-19 patients and 5 severe COVID-19 patients were seroconverted during hospitalization or follow-up period, suggesting that serological testing is a complementary assay to nucleic acid test for those symptomatic COVID-19 patients. Of note, immediate antibody responses were identified among severe cases, compared to non-severe cases. On the other hand, only one were seroconverted for asymptomatic carriers. The SARS-CoV-2 specific antibody responses were well-maintained during the observation period. Such information is of immediate relevance and would assist COVID-19 clinical diagnosis, prognosis and vaccine design

Year of Publication: 2020
Contained in: Emerging microbes & infections Vol. 9, No. 1 (2020), p. 833-836
All journal articles: Search for all articles in this journal
Language: English
Contributors: Yongchen, Zhang | Author
Shen, Han
Wang, Xinning
Shi, Xudong
Li, Yang
Yan, Jiawei
Chen, Yuxin
Gu, Bing
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: COVID-19
Letter
SARS-CoV-2
antibody responses
serology testing
viral nucleic acid
Additional Keywords: *Betacoronavirus
*Clinical Laboratory Techniques
Adolescent
Adult
Aged
Child
Coronavirus Infections
Disease Progression
Female
Humans
Male
Middle Aged
Pandemics
Pneumonia, Viral
Polymerase Chain Reaction
RNA, Viral
Serologic Tests
Time Factors
ISSN: 2222-1751
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Completed 05.05.2020
Date Revised 05.05.2020
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.1080/22221751.2020.1756699
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