Effect of treatment with silver(I) complex of metronidazole on ocular rosacea : Design and formulation of new silver drug with potent antimicrobial activity
Copyright © 2020 Elsevier GmbH. All rights reserved..
BACKGROUND: Metronidazole with well-soluble silver nitrate forms a complex with potent activity (synergism) against bacterial strains and fungi with simultaneous lower side effect than in the case of the two agents administered separately. This study aimed to establish effectiveness in the treatment of ocular rosacea with new formulation of drops and ointment with silver(I) complex of metronidazole.
METHODS: Three patients suffering from serious ophthalmic complications of acne rosacea were treated with drops and ointments applied 3 times a day for 3 months. The uncorrected visual acuity testing (UCVA), pachymetry as well as subjective and objective tear film assessment were evaluated.
RESULTS: In all patients, we have improved UCVA as well as objective and subjective evaluation of the tear film parameters. No significant differences in corneal thickness were observed.
CONCLUSION: Well soluble silver(I) complex of metronidazole might be an alternative method in ophthalmic complications of acne rosacea treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) - 61(2020) vom: 17. Apr., Seite 126531 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Waszczykowska, Arleta [VerfasserIn] |
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| Links: |
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| Themen: |
Drops |
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| Anmerkungen: |
Date Revised 27.02.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.jtemb.2020.126531 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309713080 |
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| 100 | 1 | |a Waszczykowska, Arleta |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of treatment with silver(I) complex of metronidazole on ocular rosacea |b Design and formulation of new silver drug with potent antimicrobial activity |
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| 500 | |a Date Revised 27.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier GmbH. All rights reserved. | ||
| 520 | |a BACKGROUND: Metronidazole with well-soluble silver nitrate forms a complex with potent activity (synergism) against bacterial strains and fungi with simultaneous lower side effect than in the case of the two agents administered separately. This study aimed to establish effectiveness in the treatment of ocular rosacea with new formulation of drops and ointment with silver(I) complex of metronidazole | ||
| 520 | |a METHODS: Three patients suffering from serious ophthalmic complications of acne rosacea were treated with drops and ointments applied 3 times a day for 3 months. The uncorrected visual acuity testing (UCVA), pachymetry as well as subjective and objective tear film assessment were evaluated | ||
| 520 | |a RESULTS: In all patients, we have improved UCVA as well as objective and subjective evaluation of the tear film parameters. No significant differences in corneal thickness were observed | ||
| 520 | |a CONCLUSION: Well soluble silver(I) complex of metronidazole might be an alternative method in ophthalmic complications of acne rosacea treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Drops | |
| 650 | 4 | |a Metronidazole | |
| 650 | 4 | |a Ocular rosacea | |
| 650 | 4 | |a Ointment | |
| 650 | 4 | |a Silver(I) complex | |
| 700 | 1 | |a Żyro, Dominik |e verfasserin |4 aut | |
| 700 | 1 | |a Jurowski, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a Ochocki, Justyn |e verfasserin |4 aut | |
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