Tumour-immune microenvironment in duodenal-type follicular lymphoma
© 2020 British Society for Haematology and John Wiley & Sons Ltd..
Despite duodenal-type follicular lymphoma (DTFL) being morphologically, immunophenotypically and genetically indistinguishable from nodal FL (nFL), this entity typically shows a significantly better prognosis. Here, we analysed the tumour immune microenvironments of diagnostic specimens from patients with DTFL (n = 30), limited-stage FL (LSFL; n = 19) and advanced-stage FL (ASFL; n = 31). The mean number of CD8+ tumour-infiltrating lymphocytes (TILs) in the neoplastic follicles was higher in DTFL (1,827/mm2 ) than in LSFL (1,150/mm2 ) and ASFL (1,188/mm2 ) (P = 0·002, P = 0·002, respectively). In addition, CD8+ PD1- T cells with non-exhausting phenotype were more abundant in the peripheral blood (PB) of DTFL than in LSFL and ASFL, indicating that DTFL may exhibit a better and longer-lasting T cell-mediated immune response. Moreover, whereas FOXP3+ CTLA-4+ effector regulatory T cells (eTregs) were rarely observed in the neoplastic follicles of DTFL (mean: 12/mm2 ), they were more abundant in LSFL (78/mm2 ) and ASFL (109/mm2 ) (P = 2·80 × 10-5 , P = 4·74 × 10-8 , respectively), and the numbers of eTregs correlated inversely with those of CD8+ TILs (r = -0267; P = 0·018). Furthermore, DTFL showed significantly fewer circulating FOXP3hi CD45RA- CD25hi eTregs (0·146%) than ASFL (0·497%) and healthy controls (0·639%) (P = 0·0003, P = 6·79 × 10-7 , respectively). These results suggest that the augmented anti-tumour immune reactions may contribute to a better prognosis on DTFL.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:191 |
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| Enthalten in: |
British journal of haematology - 191(2020), 2 vom: 15. Okt., Seite 243-252 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Inoue, Hiroaki [VerfasserIn] |
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| Links: |
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| Themen: |
Duodenal-type Ffollicular lymphoma |
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| Anmerkungen: |
Date Completed 16.03.2021 Date Revised 16.03.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/bjh.16715 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM309670497 |
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| 520 | |a Despite duodenal-type follicular lymphoma (DTFL) being morphologically, immunophenotypically and genetically indistinguishable from nodal FL (nFL), this entity typically shows a significantly better prognosis. Here, we analysed the tumour immune microenvironments of diagnostic specimens from patients with DTFL (n = 30), limited-stage FL (LSFL; n = 19) and advanced-stage FL (ASFL; n = 31). The mean number of CD8+ tumour-infiltrating lymphocytes (TILs) in the neoplastic follicles was higher in DTFL (1,827/mm2 ) than in LSFL (1,150/mm2 ) and ASFL (1,188/mm2 ) (P = 0·002, P = 0·002, respectively). In addition, CD8+ PD1- T cells with non-exhausting phenotype were more abundant in the peripheral blood (PB) of DTFL than in LSFL and ASFL, indicating that DTFL may exhibit a better and longer-lasting T cell-mediated immune response. Moreover, whereas FOXP3+ CTLA-4+ effector regulatory T cells (eTregs) were rarely observed in the neoplastic follicles of DTFL (mean: 12/mm2 ), they were more abundant in LSFL (78/mm2 ) and ASFL (109/mm2 ) (P = 2·80 × 10-5 , P = 4·74 × 10-8 , respectively), and the numbers of eTregs correlated inversely with those of CD8+ TILs (r = -0267; P = 0·018). Furthermore, DTFL showed significantly fewer circulating FOXP3hi CD45RA- CD25hi eTregs (0·146%) than ASFL (0·497%) and healthy controls (0·639%) (P = 0·0003, P = 6·79 × 10-7 , respectively). These results suggest that the augmented anti-tumour immune reactions may contribute to a better prognosis on DTFL | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a duodenal-type Ffollicular lymphoma | |
| 650 | 4 | |a effector regulatory T cell | |
| 650 | 4 | |a follicular lymphoma | |
| 650 | 4 | |a regulatory T cell | |
| 650 | 4 | |a tumor immune microenvironment | |
| 650 | 4 | |a tumor infiltrating T lymphocytes | |
| 700 | 1 | |a Rai, Shinya |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Hirokazu |e verfasserin |4 aut | |
| 700 | 1 | |a Espinoza, J Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Watatani, Yosaku |e verfasserin |4 aut | |
| 700 | 1 | |a Kumode, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Serizawa, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakayama, Shoko |e verfasserin |4 aut | |
| 700 | 1 | |a Taniguchi, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Morita, Yasuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Tatsumi, Yoichi |e verfasserin |4 aut | |
| 700 | 1 | |a Ashida, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumura, Itaru |e verfasserin |4 aut | |
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