A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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Enthalten in: |
Molecules (Basel, Switzerland) - 25(2020), 9 vom: 05. Mai |
Sprache: |
Englisch |
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Beteiligte Personen: |
Gambacorta, Guido [VerfasserIn] |
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Links: |
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Themen: |
15N-MASNMR |
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Anmerkungen: |
Date Completed 09.02.2021 Date Revised 09.02.2021 published: Electronic Citation Status MEDLINE |
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doi: |
10.3390/molecules25092160 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM309640024 |
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520 | |a The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation | ||
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