A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:25

Enthalten in:

Molecules (Basel, Switzerland) - 25(2020), 9 vom: 05. Mai

Sprache:

Englisch

Beteiligte Personen:

Gambacorta, Guido [VerfasserIn]
Apperley, David C [VerfasserIn]
Baxendale, Ian R [VerfasserIn]

Links:

Volltext

Themen:

15N-MASNMR
82X95S7M06
Isatin
Journal Article
Knorr pyrazole synthesis
Oxindole
Pfitzinger reaction
Pyrazole
Pyrazoles
Quinoline
Quinolines

Anmerkungen:

Date Completed 09.02.2021

Date Revised 09.02.2021

published: Electronic

Citation Status MEDLINE

doi:

10.3390/molecules25092160

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309640024