N,O-Nucleoside Analogues : Metabolic and Apoptotic Activity
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA..
Two new families of N,O-nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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Enthalten in: |
ChemistryOpen - 9(2020), 5 vom: 01. Mai, Seite 519-528 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Marraffa, Andrea [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 16.08.2021 Date Revised 28.03.2024 published: Electronic-eCollection Citation Status MEDLINE |
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doi: |
10.1002/open.202000034 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM309568544 |
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520 | |a Two new families of N,O-nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells | ||
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700 | 1 | |a Marino-Merlo, Francesca |e verfasserin |4 aut | |
700 | 1 | |a Mella, Mariella |e verfasserin |4 aut | |
700 | 1 | |a Quadrelli, Paolo |e verfasserin |4 aut | |
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