N,O-Nucleoside Analogues : Metabolic and Apoptotic Activity

© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA..

Two new families of N,O-nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

ChemistryOpen - 9(2020), 5 vom: 01. Mai, Seite 519-528

Sprache:

Englisch

Beteiligte Personen:

Marraffa, Andrea [VerfasserIn]
Presenti, Piero [VerfasserIn]
Macchi, Beatrice [VerfasserIn]
Marino-Merlo, Francesca [VerfasserIn]
Mella, Mariella [VerfasserIn]
Quadrelli, Paolo [VerfasserIn]

Links:

Volltext

Themen:

3W678R12M0
Allyl alcohol
Anthracene
Anthracenes
Apoptosis
EH46A1TLD7
Ene reactions
Isoxazolidines
Journal Article
N,O-nucleosides
Nucleosides
Oxazoles
Propanols
Research Support, Non-U.S. Gov't
Structure–activity relationship

Anmerkungen:

Date Completed 16.08.2021

Date Revised 28.03.2024

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.1002/open.202000034

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309568544