Performance evaluation of a novel multi-pinhole collimator for dopamine transporter SPECT

There is a tradeoff between spatial resolution and count sensitivity in SPECT with conventional collimators. Multi-pinhole (MPH) collimator technology has potential for concurrent improvement of resolution and sensitivity in clinical SPECT of 'small' organs. This study evaluated a novel MPH collimator specifically designed for dopamine transporter (DAT) SPECT with a triple-head SPECT camera. Count sensitivity was measured with a 99mTc point source placed on the lattice points of a 1 cm grid covering the whole field-of-view (FOV). Spatial resolution was assessed with a Derenzo type hot rod phantom. An anthropomorphic striatum phantom was scanned with total activity representative of a typical patient scan and different striatum-to-background activity concentration ratios. Recovery of striatum-to-background contrast was assessed by the contrast-recovery-coefficient. Measurements were repeated with double-head SPECT with fan-beam or low-energy-high-resolution-high-sensitivity (LEHRHS) collimators. A patient referred to DAT SPECT because of suspicion of Parkinson's disease was scanned with both LEHRHS and MPH collimators after a single tracer injection. The axial MPH sensitivity profile was approximately symmetrical around its peak, although it was shifted 7 cm towards the patient to simplify positioning. Peak sensitivity of the triple-head MPH system in the center of the FOV was 620 cps MBq-1 compared to 225 cps MBq-1 for the double-head fan-beam system. Sensitivity of the MPH system decreased towards the edges of the FOV. The full width of the sensitivity profile at 200 cps MBq-1 was 21 cm transaxially and 11 cm axially. In MPH SPECT of the Derenzo phantom all rods with ≥ 5 mm diameter were clearly visible. MPH SPECT improved striatal contrast recovery by ≥ 20% compared to fan-beam SPECT. The patient scan demonstrated good image quality of MPH SPECT with almost PET-like delineation of putamen and caudate nucleus. SPECT with dedicated MPH collimators provides considerable improvement of the resolution-sensitivity tradeoff in DAT SPECT compared to SPECT with fan-beam or LEHRHS collimators.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:65

Enthalten in:

Physics in medicine and biology - 65(2020), 16 vom: 21. Aug., Seite 165015

Sprache:

Englisch

Beteiligte Personen:

Tecklenburg, K [VerfasserIn]
Forgács, A [VerfasserIn]
Apostolova, I [VerfasserIn]
Lehnert, W [VerfasserIn]
Klutmann, S [VerfasserIn]
Csirik, J [VerfasserIn]
Garutti, E [VerfasserIn]
Buchert, R [VerfasserIn]

Links:

Volltext

Themen:

Dopamine Plasma Membrane Transport Proteins
Evaluation Study
Journal Article

Anmerkungen:

Date Completed 05.11.2020

Date Revised 05.11.2020

published: Electronic

Citation Status MEDLINE

doi:

10.1088/1361-6560/ab9067

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM30953268X