Significant differences between verbal and non-verbal intellectual scales on a perinatally HIV-infected cohort : from pediatrics to young adults

© 2020 Published by Elsevier Ltd..

Delayed neurodevelopment is a common outcome in perinatally HIV-infected children. Our aim was to assess the intellectual profile of our cohort, considering both the infection and socio-environmental related variables. A cross-sectional cohort study was undertaken at seven major hospitals in Spain belonging to the CoRISpeS cohort (n = 97). Patients were followed up according to a standard protocol. Intellectual measures, psychosocial profile and HIV infection-related data have been analysed. The average patient age was 15 years. The median CD4 cell percentage was 35% (1,59). Viral load was undetectable in 80% of the patients and 27% were on AIDS category; 38% of whom had encephalopathy. The average composite score of both crystallized intelligence (CI) and intelligence quotient (IQ) for the cohort was lower than that of the general population (p < 0.001). Results revealed a significant difference of 38% between crystallized and fluid intelligence. There was a clear association between IQ and age of diagnosis (p = 0.022); CI and CDC classification (p = 0.035), CD4 count (p = 0.011) and CD4 nadir (p = 0.001). Higher parental education was associated with better performance across all intelligence scales (p < 0.002). A regression model showed that CI was influenced by the academic level of caregivers (p = 0.002), age at start of cART (p = 0.050) and primary language (p = 0.058). Findings revealed significant differences in verbal and non-verbal intellectual scales resulting in a misleading IQ Composite score. Crystallized intelligence demonstrated the highest level of impairment despite adequate treatment and good immunovirological status, while fluid intelligence results were average. Caregiver level of education was the strongest factor across all intelligence measures.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:6

Enthalten in:

Heliyon - 6(2020), 4 vom: 26. Apr., Seite e03600

Sprache:

Englisch

Beteiligte Personen:

García-Navarro, C [VerfasserIn]
Jimenez de Ory, S [VerfasserIn]
Velo Higueras, C [VerfasserIn]
Zamora, B [VerfasserIn]
Prieto, L [VerfasserIn]
Ramos, J T [VerfasserIn]
Navarro, M L [VerfasserIn]
Escosa-García, L [VerfasserIn]
Jurado-Barba, R [VerfasserIn]
Falcón, Dolores [VerfasserIn]
Moreno, David [VerfasserIn]
González-Tomé, M I [VerfasserIn]
NeuroCoRISpeS project integrated in CoRISpe [VerfasserIn]

Links:

Volltext

Themen:

Cognition
Cognitive psychology
HIV
IQ
Intelligence
Journal Article
Learning and memory
Psychology
Vertical transmission
Virology

Anmerkungen:

Date Revised 28.09.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.1016/j.heliyon.2020.e03600

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM309521718