Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane
INTRODUCTION: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in a native collagen membrane for volume stable situations.
MATERIALS AND METHODS: HF-treated and untreated Mg were compared in direct and indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects and were divided into four groups: (a) HF-treated Mg mesh/collagen membrane, (b) untreated Mg mesh/collagen membrane (c) collagen membrane and (d) sham operation. After 6, 12 and 18 weeks, Mg degradation and bone regeneration was measured using radiological and histological methods.
RESULTS: In vitro, HF-treated Mg showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities and was degraded by mononuclear cells via phagocytosis up to 12 weeks. Untreated Mg showed partially significant more gas cavities and a fibrous tissue reaction. Bone regeneration was not significantly different between all groups.
DISCUSSION AND CONCLUSIONS: HF-Mg meshes embedded in native collagen membranes represent a volume stable and biocompatible alternative to the non-absorbable synthetic materials. HF-Mg shows less corrosion and is degraded by phagocytosis. However, the application of membranes did not result in higher bone regeneration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
International journal of molecular sciences - 21(2020), 9 vom: 28. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Barbeck, Mike [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.02.2021 Date Revised 02.02.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms21093098 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM30937698X |
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| 100 | 1 | |a Barbeck, Mike |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Degradation, Bone Regeneration and Tissue Response of an Innovative Volume Stable Magnesium-Supported GBR/GTR Barrier Membrane |
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| 520 | |a INTRODUCTION: Bioresorbable collagenous barrier membranes are used to prevent premature soft tissue ingrowth and to allow bone regeneration. For volume stable indications, only non-absorbable synthetic materials are available. This study investigates a new bioresorbable hydrofluoric acid (HF)-treated magnesium (Mg) mesh in a native collagen membrane for volume stable situations | ||
| 520 | |a MATERIALS AND METHODS: HF-treated and untreated Mg were compared in direct and indirect cytocompatibility assays. In vivo, 18 New Zealand White Rabbits received each four 8 mm calvarial defects and were divided into four groups: (a) HF-treated Mg mesh/collagen membrane, (b) untreated Mg mesh/collagen membrane (c) collagen membrane and (d) sham operation. After 6, 12 and 18 weeks, Mg degradation and bone regeneration was measured using radiological and histological methods | ||
| 520 | |a RESULTS: In vitro, HF-treated Mg showed higher cytocompatibility. Histopathologically, HF-Mg prevented gas cavities and was degraded by mononuclear cells via phagocytosis up to 12 weeks. Untreated Mg showed partially significant more gas cavities and a fibrous tissue reaction. Bone regeneration was not significantly different between all groups | ||
| 520 | |a DISCUSSION AND CONCLUSIONS: HF-Mg meshes embedded in native collagen membranes represent a volume stable and biocompatible alternative to the non-absorbable synthetic materials. HF-Mg shows less corrosion and is degraded by phagocytosis. However, the application of membranes did not result in higher bone regeneration | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a GBR/GTR membrane | |
| 650 | 4 | |a barrier membrane | |
| 650 | 4 | |a collagen | |
| 650 | 4 | |a degradation | |
| 650 | 4 | |a histomorphometry | |
| 650 | 4 | |a in vivo | |
| 650 | 4 | |a magnesium | |
| 650 | 4 | |a tissue reaction | |
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| 700 | 1 | |a Kühnel, Lennart |e verfasserin |4 aut | |
| 700 | 1 | |a Witte, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Pissarek, Jens |e verfasserin |4 aut | |
| 700 | 1 | |a Precht, Clarissa |e verfasserin |4 aut | |
| 700 | 1 | |a Xiong, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Krastev, Rumen |e verfasserin |4 aut | |
| 700 | 1 | |a Wegner, Nils |e verfasserin |4 aut | |
| 700 | 1 | |a Walther, Frank |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Ole |e verfasserin |4 aut | |
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