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The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients

OBJECTIVE: This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People's Hospital, enrolled from Jan 5 to Feb 13, 2020

METHODS: The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected

RESULTS: COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin

CONCLUSIONS: Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection

Year of Publication: 2020
Contained in: Inflammation research : official journal of the European Histamine Research Society ... [et al. Vol. 69, No. 6 (2020), p. 599-606
All journal articles: Search for all articles in this journal
Language: English
Contributors: Yuan, Jing | Author
Zou, Rougrong
Zeng, Lijiao
Kou, Shanglong
Lan, Jianfeng
Li, Xiaohe
Liang, Yanhua
Ding, Xiaoyan
Tan, Guoyu
Tang, Shenghong
Liu, Lei
Liu, Yingxia
Pan, Yanchao
Wang, Zhaoqin
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: 2494G1JF75
CK
COVID-19
Clearance ratio
EC 1.1.1.27
EC 2.7.3.2
Journal Article
LDH
O3J8G9O825
lopinavir-ritonavir drug combination
Additional Keywords: Adolescent
Adult
Aged
Child
Child, Preschool
China
Coronavirus Infections
Creatine Kinase
Drug Combinations
Humans
Interferon-alpha
L-Lactate Dehydrogenase
Lopinavir
Middle Aged
Pandemics
Pneumonia, Viral
Polymerase Chain Reaction
RNA, Viral
Retrospective Studies
Ritonavir
Young Adult
ISSN: 1420-908X
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Completed 07.05.2020
Date Revised 07.05.2020
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.1007/s00011-020-01342-0
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520 |a METHODS: The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected 
520 |a RESULTS: COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin 
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