Mesoscale organization of the chromatin fiber
Copyright © 2020 Elsevier Ltd. All rights reserved..
The proper organization of the physical genome is essential to facilitate DNA-templated processes from transcription to replication to DNA repair. Genome-wide studies over the past two decades have provided us with a detailed understanding of the positions and modification states of nucleosomes across the genomes of many organisms, as well as an increasingly mature understanding of chromosome organization at the kilobase to megabase scale. Here, we explore chromatin organization at intermediate scales of ∼2-10 nucleosomes, from early views supporting a secondary structural element known as the 30nm fiber to more recent 'sea of nucleosomes' models.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Current opinion in genetics & development - 61(2020) vom: 11. Apr., Seite 32-36 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Krietenstein, Nils [VerfasserIn] |
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| Links: |
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| Themen: |
9007-49-2 |
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| Anmerkungen: |
Date Completed 14.06.2021 Date Revised 14.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.gde.2020.02.022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308906047 |
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| 520 | |a The proper organization of the physical genome is essential to facilitate DNA-templated processes from transcription to replication to DNA repair. Genome-wide studies over the past two decades have provided us with a detailed understanding of the positions and modification states of nucleosomes across the genomes of many organisms, as well as an increasingly mature understanding of chromosome organization at the kilobase to megabase scale. Here, we explore chromatin organization at intermediate scales of ∼2-10 nucleosomes, from early views supporting a secondary structural element known as the 30nm fiber to more recent 'sea of nucleosomes' models | ||
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