Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines
A new synthetic method toward direct C-N bond formation through saturated C-H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C-H substrates or cyclohexane to form the corresponding aromatic secondary amines in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Organic & biomolecular chemistry - 18(2020), 17 vom: 06. Mai, Seite 3263-3268 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yao, Hua [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 12.04.2021 Date Revised 12.04.2021 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d0ob00491j |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308867629 |
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| 245 | 1 | 0 | |a Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines |
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| 500 | |a Date Revised 12.04.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A new synthetic method toward direct C-N bond formation through saturated C-H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C-H substrates or cyclohexane to form the corresponding aromatic secondary amines in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Xie, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Xiaoyang |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Shengzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Sen |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Zhaohua |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:18 |g year:2020 |g number:17 |g day:06 |g month:05 |g pages:3263-3268 |
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