Latency of subthalamic nucleus deep brain stimulation-evoked cortical activity as a potential biomarker for postoperative motor side effects
Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved..
OBJECTIVE: Here, we investigate whether cortical activation predicts motor side effects of deep brain stimulation (DBS) and whether these potential biomarkers have utility under general anesthesia.
METHODS: We recorded scalp potentials elicited by DBS during surgery (n = 11), both awake and under general anesthesia, and in an independent ambulatory cohort (n = 8). Across a range of stimulus configurations, we measured the amplitude and timing of short- and long-latency response components and linked them to motor side effects.
RESULTS: Regardless of anesthesia state, in both cohorts, DBS settings with capsular side effects elicited early responses with peak latencies clustering at <1 ms. This early response was preserved under anesthesia in all participants (11/11). In contrast, the long-latency components were suppressed completely in 6/11 participants. Finally, the latency of the earliest response could predict the presence of postoperative motor side effects both awake and under general anesthesia (84.8% and 75.8% accuracy, awake and under anesthesia, respectively).
CONCLUSION: DBS elicits short-latency cortical activation, both awake and under general anesthesia, which appears to reveal interactions between the stimulus and the corticospinal tract.
SIGNIFICANCE: Short-latency evoked cortical activity can potentially be used to aid both DBS lead placement and post-operative programming.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:131 |
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Enthalten in: |
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 131(2020), 6 vom: 21. Juni, Seite 1221-1229 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Irwin, Zachary T [VerfasserIn] |
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Links: |
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Themen: |
Anesthesia |
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Anmerkungen: |
Date Completed 25.01.2021 Date Revised 02.06.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.clinph.2020.02.021 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM308838785 |
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100 | 1 | |a Irwin, Zachary T |e verfasserin |4 aut | |
245 | 1 | 0 | |a Latency of subthalamic nucleus deep brain stimulation-evoked cortical activity as a potential biomarker for postoperative motor side effects |
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500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. | ||
520 | |a OBJECTIVE: Here, we investigate whether cortical activation predicts motor side effects of deep brain stimulation (DBS) and whether these potential biomarkers have utility under general anesthesia | ||
520 | |a METHODS: We recorded scalp potentials elicited by DBS during surgery (n = 11), both awake and under general anesthesia, and in an independent ambulatory cohort (n = 8). Across a range of stimulus configurations, we measured the amplitude and timing of short- and long-latency response components and linked them to motor side effects | ||
520 | |a RESULTS: Regardless of anesthesia state, in both cohorts, DBS settings with capsular side effects elicited early responses with peak latencies clustering at <1 ms. This early response was preserved under anesthesia in all participants (11/11). In contrast, the long-latency components were suppressed completely in 6/11 participants. Finally, the latency of the earliest response could predict the presence of postoperative motor side effects both awake and under general anesthesia (84.8% and 75.8% accuracy, awake and under anesthesia, respectively) | ||
520 | |a CONCLUSION: DBS elicits short-latency cortical activation, both awake and under general anesthesia, which appears to reveal interactions between the stimulus and the corticospinal tract | ||
520 | |a SIGNIFICANCE: Short-latency evoked cortical activity can potentially be used to aid both DBS lead placement and post-operative programming | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Anesthesia | |
650 | 4 | |a Biomarker | |
650 | 4 | |a Deep brain stimulation | |
650 | 4 | |a Evoked potentials | |
650 | 7 | |a Biomarkers |2 NLM | |
700 | 1 | |a Awad, Mohammad Z |e verfasserin |4 aut | |
700 | 1 | |a Gonzalez, Christopher L |e verfasserin |4 aut | |
700 | 1 | |a Nakhmani, Arie |e verfasserin |4 aut | |
700 | 1 | |a Bentley, J Nicole |e verfasserin |4 aut | |
700 | 1 | |a Moore, Thomas A |e verfasserin |4 aut | |
700 | 1 | |a Smithson, Kenneth G |e verfasserin |4 aut | |
700 | 1 | |a Guthrie, Barton L |e verfasserin |4 aut | |
700 | 1 | |a Walker, Harrison C |e verfasserin |4 aut | |
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