Latency of subthalamic nucleus deep brain stimulation-evoked cortical activity as a potential biomarker for postoperative motor side effects

Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved..

OBJECTIVE: Here, we investigate whether cortical activation predicts motor side effects of deep brain stimulation (DBS) and whether these potential biomarkers have utility under general anesthesia.

METHODS: We recorded scalp potentials elicited by DBS during surgery (n = 11), both awake and under general anesthesia, and in an independent ambulatory cohort (n = 8). Across a range of stimulus configurations, we measured the amplitude and timing of short- and long-latency response components and linked them to motor side effects.

RESULTS: Regardless of anesthesia state, in both cohorts, DBS settings with capsular side effects elicited early responses with peak latencies clustering at <1 ms. This early response was preserved under anesthesia in all participants (11/11). In contrast, the long-latency components were suppressed completely in 6/11 participants. Finally, the latency of the earliest response could predict the presence of postoperative motor side effects both awake and under general anesthesia (84.8% and 75.8% accuracy, awake and under anesthesia, respectively).

CONCLUSION: DBS elicits short-latency cortical activation, both awake and under general anesthesia, which appears to reveal interactions between the stimulus and the corticospinal tract.

SIGNIFICANCE: Short-latency evoked cortical activity can potentially be used to aid both DBS lead placement and post-operative programming.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:131

Enthalten in:

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology - 131(2020), 6 vom: 21. Juni, Seite 1221-1229

Sprache:

Englisch

Beteiligte Personen:

Irwin, Zachary T [VerfasserIn]
Awad, Mohammad Z [VerfasserIn]
Gonzalez, Christopher L [VerfasserIn]
Nakhmani, Arie [VerfasserIn]
Bentley, J Nicole [VerfasserIn]
Moore, Thomas A [VerfasserIn]
Smithson, Kenneth G [VerfasserIn]
Guthrie, Barton L [VerfasserIn]
Walker, Harrison C [VerfasserIn]

Links:

Volltext

Themen:

Anesthesia
Biomarker
Biomarkers
Deep brain stimulation
Evoked potentials
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 25.01.2021

Date Revised 02.06.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.clinph.2020.02.021

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM308838785