Cone-beam computed tomography for organ motion evaluation in locally advanced rectal cancer patients

PURPOSE: Due to a reported dose-response relationship in rectal cancer radiotherapy, a greater interest in dose intensification on small boost volume arises. Considering the need of an appropriate target movements evaluation, this retrospective study aimed to use cone-beam computed tomography (CBCT) for GTV and mesorectum organ motion (OM) evaluation, in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemo-radiotherapy, in prone and supine position.

METHODS: Thirty-two LARC patients were analyzed. GTV and mesorectum were delineated on MRI co-registrated with CT simulation. GTV and mesorectum OM was estimated on all CBCTs, performed during treatment, co-registrated with CT simulation. OM evaluation was obtained, as mean shift in left and right (L-R), postero-anterior (P-A) and cranio-caudal (Cr-C) directions. Volumes variability was calculated by DICE index.

RESULTS: A total of 296 CBCTs were analyzed. Mean shifts of the GTV and mesorectum in prone position were - 0.16 cm and 0.15 cm in L-R direction, 0.28 cm and - 0.40 cm in P-A direction, and 0.14 cm and - 0.21 cm, in Cr-C direction; for supine position the mean shifts of the GTV were - 0.10 cm and 0.17 cm in R-L direction, 0.26 cm and - 0.23 cm in A-P direction, 0.09 cm and - 0.11 cm in Cr-C direction. Mean DICE index for GTV and mesorectum was 0.74 and 0.86, in prone position, and 0.78 and 0.89 in supine position, respectively.

CONCLUSION: GTV and mesorectum OM was less than 4 mm in all directions in both positions, with a 1 mm less deviation in supine position. CBCTs resulted effective for OM assessment, and it could be an appropriate method for the implementation on an intensification treatment.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:126

Enthalten in:

La Radiologia medica - 126(2021), 1 vom: 15. Jan., Seite 147-154

Sprache:

Englisch

Beteiligte Personen:

Rosa, Consuelo [VerfasserIn]
Caravatta, Luciana [VerfasserIn]
Di Tommaso, Monica [VerfasserIn]
Fasciolo, David [VerfasserIn]
Gasparini, Lucrezia [VerfasserIn]
Di Guglielmo, Fiorella Cristina [VerfasserIn]
Augurio, Antonietta [VerfasserIn]
Vinciguerra, Annamaria [VerfasserIn]
Vecchi, Claudio [VerfasserIn]
Genovesi, Domenico [VerfasserIn]

Links:

Volltext

Themen:

Cone-beam computed tomography
Dose intensification
Journal Article
Organ motion
Radiotherapy
Rectal cancer

Anmerkungen:

Date Completed 22.02.2021

Date Revised 22.02.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s11547-020-01193-z

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM308819985