Aptasensors for viral diagnostics
Copyright © 2015 Published by Elsevier B.V..
Novel viral diagnostic tools need to be affordable, fast, accurate and easy to use with sensitivity and specificity equivalent or superior to current standards. At present, viral diagnostics are based on direct detection of viral components or indirect detection by measuring antibodies generated in response to viral infection. While sensitivity of detection and quantification are still important challenges, we expect major advances from new assay formats and synthetic binding molecules, such as aptamers. Compared to traditional antibody-based detection, aptamers could provide faster adaptation to continuously evolving virus strains and higher discriminating capacity between specific virus serotypes. Aptamers are very stable and easily modifiable, so are ideal molecules for detection and chemical sensing applications. Here, we review the use of aptasensors for detection of viral pathogens and consider the feasibility of aptasensors to become standard devices for point-of-care diagnostics of viruses.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:74 |
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| Enthalten in: |
Trends in analytical chemistry : TRAC - 74(2015) vom: 01. Dez., Seite 58-67 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van den Kieboom, Corné H [VerfasserIn] |
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| Links: |
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| Themen: |
Antibody |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.trac.2015.05.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308724682 |
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| 520 | |a Novel viral diagnostic tools need to be affordable, fast, accurate and easy to use with sensitivity and specificity equivalent or superior to current standards. At present, viral diagnostics are based on direct detection of viral components or indirect detection by measuring antibodies generated in response to viral infection. While sensitivity of detection and quantification are still important challenges, we expect major advances from new assay formats and synthetic binding molecules, such as aptamers. Compared to traditional antibody-based detection, aptamers could provide faster adaptation to continuously evolving virus strains and higher discriminating capacity between specific virus serotypes. Aptamers are very stable and easily modifiable, so are ideal molecules for detection and chemical sensing applications. Here, we review the use of aptasensors for detection of viral pathogens and consider the feasibility of aptasensors to become standard devices for point-of-care diagnostics of viruses | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Aptamer | |
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| 650 | 4 | |a Detection | |
| 650 | 4 | |a Diagnostics | |
| 650 | 4 | |a Pathogen | |
| 650 | 4 | |a Point of care | |
| 650 | 4 | |a Sensor | |
| 650 | 4 | |a Serotype | |
| 650 | 4 | |a Virus | |
| 700 | 1 | |a van der Beek, Samantha L |e verfasserin |4 aut | |
| 700 | 1 | |a Mészáros, Tamás |e verfasserin |4 aut | |
| 700 | 1 | |a Gyurcsányi, Róbert E |e verfasserin |4 aut | |
| 700 | 1 | |a Ferwerda, Gerben |e verfasserin |4 aut | |
| 700 | 1 | |a de Jonge, Marien I |e verfasserin |4 aut | |
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