Synthetic studies towards anti-SARS agents : application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

Copyright © 2004 Elsevier Ltd. All rights reserved..

AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV Mpro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.

Medienart:

E-Artikel

Erscheinungsjahr:

2004

Erschienen:

2004

Enthalten in:

Zur Gesamtaufnahme - volume:45

Enthalten in:

Tetrahedron letters - 45(2004), 52 vom: 20. Dez., Seite 9501-9504

Sprache:

Englisch

Beteiligte Personen:

Chng, Shu-Sin [VerfasserIn]
Hoang, Truong-Giang [VerfasserIn]
Wayne Lee, Wei-Woon [VerfasserIn]
Tham, Mun-Pun [VerfasserIn]
Ling, Hui Yvonne [VerfasserIn]
Loh, Teck-Peng [VerfasserIn]

Links:

Volltext

Themen:

AG7088
Anti-SARS agents
Diastereoselective
Indium-mediated allylation
Journal Article

Anmerkungen:

Date Revised 18.04.2020

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1016/j.tetlet.2004.10.146

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM308723635