Physiological Acclimatization of the Liver to 180-Day Isolation and the Mars Solar Day

Copyright © 2020 Hailong Chen et al..

Physiological changes in humans are evident under environmental conditions similar to those on a Mars mission involving both a space factor (long-term isolation) and a time factor (the Mars solar day). However, very few studies have investigated the response of the liver to those conditions. Serum protein levels, bilirubin levels, aminotransferase activities, blood alkaline phosphatase, gamma-glutamyltransferase, lipid levels, and serum cytokines interleukin-6 and interferon-γ levels were analyzed 30 days before the mock mission; on days 2, 30, 60, 75, 90, 105, 120, 150, and 175 of the mission; and 30 days after the mission, in four subjects in 4-person 180-day Controlled Ecological Life Support System Experiment. Serum protein levels (total protein and globulin) decreased and bilirubin increased under the isolation environment from day 2 and exhibited chronic acclimatization from days 30 to 175. Effects of the Mars solar day were evident on day 75. Blood lipid levels were somewhat affected. No obvious peak in any enzyme level was detected during the mission. The change tendency of these results indicated that future studies should explore whether protein parameters especially globulin could serve as indicators of immunological function exposure to the stress of a Mars mission.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:2020

Enthalten in:

BioMed research international - 2020(2020) vom: 18., Seite 2796510

Sprache:

Englisch

Beteiligte Personen:

Chen, Hailong [VerfasserIn]
Lv, Ke [VerfasserIn]
Ji, Guohua [VerfasserIn]
Yuan, Yanhong [VerfasserIn]
Lu, Liang [VerfasserIn]
Liang, Fengji [VerfasserIn]
Li, Kai [VerfasserIn]
Xu, Zi [VerfasserIn]
Xiong, Jianghui [VerfasserIn]
Qu, Lina [VerfasserIn]
Li, Yinghui [VerfasserIn]

Links:

Volltext

Themen:

82115-62-6
Alkaline Phosphatase
Bilirubin
Blood Proteins
EC 2.3.2.2
EC 2.6.1.-
EC 3.1.3.1
Gamma-Glutamyltransferase
Globulins
Interferon-gamma
Interleukin-6
Journal Article
RFM9X3LJ49
Transaminases

Anmerkungen:

Date Completed 07.01.2021

Date Revised 07.01.2021

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.1155/2020/2796510

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM308657640