Risk factors for development and mortality of invasive pulmonary Aspergillosis in kidney transplantation recipients
Invasive pulmonary aspergillosis (IPA) is a high mortality opportunistic infection among kidney transplant recipients. This study assessed the risk factors and outcomes of IPA after KT. A retrospective study was conducted at a tertiary-care referral hospital in Korea. Electronic medical records of patients diagnosed with IPA after KT between February 1995 and March 2015 were reviewed. The control patients comprised two patients who received KT before and after each IPA case. Twenty-six cases were diagnosed with IPA among 1963 recipients at a median of 58 years old. The most common cause of end-stage renal disease was diabetic nephropathy. The median time to diagnosis was 161 days. Delayed graft function was associated with the development of IPA. The overall 12-week mortality rate of IPA was 57.5%. Serum GM level ≥ 2 and BAL GM level ≥ 5 were associated with 12-week mortality in the Kaplan-Meier survival analyses. Approximately half of IPA in KT recipients developed during the late posttransplant period (> 6 months), especially after treatment for acute rejection. Careful monitoring for IPA is required in patients with delayed graft function, DM, and who received rejection therapy. Higher serum and BAL GM were associated with 12-week mortality.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
|---|---|
| Enthalten in: |
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 39(2020), 8 vom: 03. Aug., Seite 1543-1550 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Seok, Hyeri [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antifungal Agents |
|---|
| Anmerkungen: |
Date Completed 16.03.2021 Date Revised 19.07.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10096-020-03871-2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM308642147 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM308642147 | ||
| 003 | DE-627 | ||
| 005 | 20231225132151.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10096-020-03871-2 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1028.xml |
| 035 | |a (DE-627)NLM308642147 | ||
| 035 | |a (NLM)32279121 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Seok, Hyeri |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk factors for development and mortality of invasive pulmonary Aspergillosis in kidney transplantation recipients |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.03.2021 | ||
| 500 | |a Date Revised 19.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Invasive pulmonary aspergillosis (IPA) is a high mortality opportunistic infection among kidney transplant recipients. This study assessed the risk factors and outcomes of IPA after KT. A retrospective study was conducted at a tertiary-care referral hospital in Korea. Electronic medical records of patients diagnosed with IPA after KT between February 1995 and March 2015 were reviewed. The control patients comprised two patients who received KT before and after each IPA case. Twenty-six cases were diagnosed with IPA among 1963 recipients at a median of 58 years old. The most common cause of end-stage renal disease was diabetic nephropathy. The median time to diagnosis was 161 days. Delayed graft function was associated with the development of IPA. The overall 12-week mortality rate of IPA was 57.5%. Serum GM level ≥ 2 and BAL GM level ≥ 5 were associated with 12-week mortality in the Kaplan-Meier survival analyses. Approximately half of IPA in KT recipients developed during the late posttransplant period (> 6 months), especially after treatment for acute rejection. Careful monitoring for IPA is required in patients with delayed graft function, DM, and who received rejection therapy. Higher serum and BAL GM were associated with 12-week mortality | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Invasive pulmonary aspergillosis | |
| 650 | 4 | |a Kidney transplantation | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Risk factor | |
| 650 | 7 | |a Antifungal Agents |2 NLM | |
| 700 | 1 | |a Huh, Kyungmin |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Sun Young |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Cheol-In |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Doo Ryeon |e verfasserin |4 aut | |
| 700 | 1 | |a Huh, Woo Seong |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Jae Berm |e verfasserin |4 aut | |
| 700 | 1 | |a Peck, Kyong Ran |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology |d 1988 |g 39(2020), 8 vom: 03. Aug., Seite 1543-1550 |w (DE-627)NLM012620742 |x 1435-4373 |7 nnns |
| 773 | 1 | 8 | |g volume:39 |g year:2020 |g number:8 |g day:03 |g month:08 |g pages:1543-1550 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10096-020-03871-2 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 39 |j 2020 |e 8 |b 03 |c 08 |h 1543-1550 | ||