Methylation map genes can be critical in determining the methylome of intracranial aneurysm patients
Aim: Intracranial aneurysm is often asymptomatic until the time of rupture. Elevated homocysteine is reported in vascular diseases. Identifying early events in homocysteine metabolism through methylation map genes may prevent fatality. Materials & methods: In the present study, we investigated the role of variants in methylation map genes in ethnically matched 480 individuals that can influence the homocysteine levels and promote development of aneurysm. Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm. Conclusion: The associated allelic variants in these genes have functional relevance and are predictive of decreased expression indicative of altered methylation levels that may result in elevated homocysteine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Epigenomics - 12(2020), 10 vom: 01. Mai, Seite 859-871 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shafeeque, Chathathayil Mohammedali [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 18.08.2021 Date Revised 18.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2217/epi-2019-0280 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM308520874 |
|---|
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| 100 | 1 | |a Shafeeque, Chathathayil Mohammedali |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Methylation map genes can be critical in determining the methylome of intracranial aneurysm patients |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 18.08.2021 | ||
| 500 | |a Date Revised 18.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: Intracranial aneurysm is often asymptomatic until the time of rupture. Elevated homocysteine is reported in vascular diseases. Identifying early events in homocysteine metabolism through methylation map genes may prevent fatality. Materials & methods: In the present study, we investigated the role of variants in methylation map genes in ethnically matched 480 individuals that can influence the homocysteine levels and promote development of aneurysm. Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm. Conclusion: The associated allelic variants in these genes have functional relevance and are predictive of decreased expression indicative of altered methylation levels that may result in elevated homocysteine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a BHMT | |
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| 650 | 4 | |a MTHFR | |
| 650 | 4 | |a MTR | |
| 650 | 4 | |a MTRR | |
| 650 | 4 | |a aneurysm | |
| 650 | 4 | |a homocysteine | |
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| 650 | 7 | |a methionine synthase reductase |2 NLM | |
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| 650 | 7 | |a Ferredoxin-NADP Reductase |2 NLM | |
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| 650 | 7 | |a MTR protein, human |2 NLM | |
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| 650 | 7 | |a DNA (Cytosine-5-)-Methyltransferase 1 |2 NLM | |
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| 700 | 1 | |a Sathyan, Sanish |e verfasserin |4 aut | |
| 700 | 1 | |a Saradalekshmi, Koramannil Radha |e verfasserin |4 aut | |
| 700 | 1 | |a Premkumar, Sasi |e verfasserin |4 aut | |
| 700 | 1 | |a Allapatt, Jacob P |e verfasserin |4 aut | |
| 700 | 1 | |a Banerjee, Moinak |e verfasserin |4 aut | |
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