Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke
OBJECTIVE: The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS.
PATIENTS AND METHODS: Materials and methods: The study included 100 patients with AIS. As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%. The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%. Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries.
RESULTS: Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%. In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004).
CONCLUSION: Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain.
Medienart: |
Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
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Enthalten in: |
Wiadomosci lekarskie (Warsaw, Poland : 1960) - 73(2020), 2 vom: 31., Seite 272-277 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Semenenko, Andrii I [VerfasserIn] |
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Themen: |
0.9% NaCl |
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Anmerkungen: |
Date Completed 13.05.2020 Date Revised 13.05.2020 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM308335635 |
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LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
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100 | 1 | |a Semenenko, Andrii I |e verfasserin |4 aut | |
245 | 1 | 0 | |a Influence of different qualitative composition of infusion solutions on cerebral hemodynamics in patients with acute ischemic stroke |
264 | 1 | |c 2020 | |
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500 | |a Date Completed 13.05.2020 | ||
500 | |a Date Revised 13.05.2020 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVE: The aim: Investigate the effect of 0.9% NaCl, HES 130, HAES-LX-5% and mannitol 15% on cerebral hemodynamics in patients with AIS | ||
520 | |a PATIENTS AND METHODS: Materials and methods: The study included 100 patients with AIS. As the investigated solutions were used: isosmolar 0.9% NaCl, hyperosmolar mannitol 15%, colloid-isoosmolar HES 130, colloid-hyperosmolar HAES-LX-5%. The control group received only 0.9% NaCl compared: 0.9% NaCl+HES 130, 0.9% NaCl+HAES-LX-5%, 0.9% NaCl+mannitol 15%. Evaluation of cerebral hemodynamic (indexes of cerebral blood flow) was performed using doppler ultrasound of cerebral arteries | ||
520 | |a RESULTS: Results: The dynamics of specific volume velocity of blood flow per 100 grams of brain substance indicates that in the group of 0.9% NaCl and 0.9% NaCl+mannitol is the tendency to decrease the blood flow of the brain during 7 days of treatment, respectively: 2.8% and 7.5%. In patients with HES 130 solution cerebral blood flow increases by 14.2%, whereas when applied HAES-LX-5% during 7 days, it increases by 43.2% (p=0.004) | ||
520 | |a CONCLUSION: Conclusions: The analysis of the data of treatment the patients with AIS showed the best effect (p=0.004) of improvement of the cerebral circulation in the use of the polyfunctional infusion solution HAES-LX-5% unlike the 0.9% NaCl group and group of 0.9% NaCl+mannitol where was a decrease of the dynamics of cerebral blood flow, which could lead to hypoperfusion of the brain | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a 0.9% NaCl | |
650 | 4 | |a HES 130 | |
650 | 4 | |a acute ischemic stroke | |
650 | 4 | |a HAES-LX-5% | |
650 | 4 | |a mannitol | |
650 | 4 | |a infusion therapy | |
650 | 7 | |a Hydroxyethyl Starch Derivatives |2 NLM | |
650 | 7 | |a Mannitol |2 NLM | |
650 | 7 | |a 3OWL53L36A |2 NLM | |
700 | 1 | |a Khrebtii, Halyna I |e verfasserin |4 aut | |
700 | 1 | |a Malyk, Svetlana L |e verfasserin |4 aut | |
700 | 1 | |a Dmytriiev, Dmytro V |e verfasserin |4 aut | |
700 | 1 | |a Bodnar, Roksolana Ya |e verfasserin |4 aut | |
700 | 1 | |a Zheliba, Lesia M |e verfasserin |4 aut | |
700 | 1 | |a Lomakina, Yuliia V |e verfasserin |4 aut | |
700 | 1 | |a Alsalama, Mohammad Wathek O |e verfasserin |4 aut | |
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