The Phenotypic Characterization of the Cammalleri Sisters, an Example of Exceptional Longevity

This article shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semisupercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semisupercentenarians and supercentenarians. Different studies have been published on supercentenarians, but to the best of our knowledge, this is the only concerning two sisters and the most detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:23

Enthalten in:

Rejuvenation research - 23(2020), 6 vom: 15. Dez., Seite 476-484

Sprache:

Englisch

Beteiligte Personen:

Accardi, Giulia [VerfasserIn]
Aiello, Anna [VerfasserIn]
Aprile, Stefano [VerfasserIn]
Caldarella, Rosalia [VerfasserIn]
Cammarata, Giuseppe [VerfasserIn]
Carru, Ciriaco [VerfasserIn]
Caruso, Calogero [VerfasserIn]
Ciaccio, Marcello [VerfasserIn]
Colomba, Paolo [VerfasserIn]
Galimberti, Damiano [VerfasserIn]
Gambino, Caterina Maria [VerfasserIn]
Davinelli, Sergio [VerfasserIn]
De Vivo, Immaculata [VerfasserIn]
Ligotti, Mattia Emanuela [VerfasserIn]
Vasto, Sonya [VerfasserIn]
Zinellu, Angelo [VerfasserIn]
Candore, Giuseppina [VerfasserIn]

Links:

Volltext

Themen:

Inflammation
Journal Article
Longevity
Oxidative stress
Semisupercentenarian
Supercentenarian

Anmerkungen:

Date Completed 14.09.2021

Date Revised 14.09.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1089/rej.2019.2299

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM308279530