Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin : Bradyarrhythmias, tachycardias, and prolonged interictal QT interval
Wiley Periodicals, Inc. © 2020 International League Against Epilepsy..
OBJECTIVE: To determine electrical changes in the heart in a chronic, nonstatus model of epilepsy.
METHODS: Electrocorticography (ECoG) and electrocardiography (ECG) of nine animals (five made epileptic by intrahippocampal injection of tetanus neurotoxin (TeNT) and four controls), are monitored continuously by radiotelemetry for up to 7 weeks.
RESULTS: Epileptic animals develop a median of 168 seizures, with postictal tachycardias reaching a mean of 487 beats/min and lasting a mean of 661 seconds. Ictal changes in heart rate include tachycardia and in the case of convulsive seizures, bradyarrhythmias resembling Mobitz type 1 second-degree atrioventricular block; notably the P-R interval increased before block. Postictally, the amplitude of T wave increases. Interictally, QT dependence on RR is modest and conventional QT corrections prove ineffective. Interictal QT intervals, measured at a heart rate of 400 bpm, increased from 65 to 75 ms, an increase dependent on seizure incidence over the preceding 10-14 days.
SIGNIFICANCE: Repeated seizures induce a sustained tachycardia and increase in QT interval of the ECG and evoke arrhythmias including periods of atrioventricular block during Racine type 4 and 5 seizures. These changes in cardiac function may predispose to development in fatal arrhythmias and sudden death in humans with epilepsy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
|---|---|
| Enthalten in: |
Epilepsia - 61(2020), 4 vom: 15. Apr., Seite 798-809 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jefferys, John G R [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cardiac dysfunction |
|---|
| Anmerkungen: |
Date Completed 16.10.2020 Date Revised 16.10.2020 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/epi.16479 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM307882454 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM307882454 | ||
| 003 | DE-627 | ||
| 005 | 20231225130537.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/epi.16479 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1026.xml |
| 035 | |a (DE-627)NLM307882454 | ||
| 035 | |a (NLM)32201948 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Jefferys, John G R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cardiac effects of repeated focal seizures in rats induced by intrahippocampal tetanus toxin |b Bradyarrhythmias, tachycardias, and prolonged interictal QT interval |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.10.2020 | ||
| 500 | |a Date Revised 16.10.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Wiley Periodicals, Inc. © 2020 International League Against Epilepsy. | ||
| 520 | |a OBJECTIVE: To determine electrical changes in the heart in a chronic, nonstatus model of epilepsy | ||
| 520 | |a METHODS: Electrocorticography (ECoG) and electrocardiography (ECG) of nine animals (five made epileptic by intrahippocampal injection of tetanus neurotoxin (TeNT) and four controls), are monitored continuously by radiotelemetry for up to 7 weeks | ||
| 520 | |a RESULTS: Epileptic animals develop a median of 168 seizures, with postictal tachycardias reaching a mean of 487 beats/min and lasting a mean of 661 seconds. Ictal changes in heart rate include tachycardia and in the case of convulsive seizures, bradyarrhythmias resembling Mobitz type 1 second-degree atrioventricular block; notably the P-R interval increased before block. Postictally, the amplitude of T wave increases. Interictally, QT dependence on RR is modest and conventional QT corrections prove ineffective. Interictal QT intervals, measured at a heart rate of 400 bpm, increased from 65 to 75 ms, an increase dependent on seizure incidence over the preceding 10-14 days | ||
| 520 | |a SIGNIFICANCE: Repeated seizures induce a sustained tachycardia and increase in QT interval of the ECG and evoke arrhythmias including periods of atrioventricular block during Racine type 4 and 5 seizures. These changes in cardiac function may predispose to development in fatal arrhythmias and sudden death in humans with epilepsy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a QT correction | |
| 650 | 4 | |a QT prolongation | |
| 650 | 4 | |a cardiac dysfunction | |
| 650 | 4 | |a epilepsy | |
| 650 | 7 | |a Neurotoxins |2 NLM | |
| 650 | 7 | |a Tetanus Toxin |2 NLM | |
| 700 | 1 | |a Ashby-Lumsden, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Lovick, Thelma A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Epilepsia |d 1954 |g 61(2020), 4 vom: 15. Apr., Seite 798-809 |w (DE-627)NLM000016195 |x 1528-1167 |7 nnns |
| 773 | 1 | 8 | |g volume:61 |g year:2020 |g number:4 |g day:15 |g month:04 |g pages:798-809 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/epi.16479 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 61 |j 2020 |e 4 |b 15 |c 04 |h 798-809 | ||