Guiding significance of pathological diagnosis in watch and wait strategy for locally advanced rectal cancer patients after neoadjuvant therapy
Some studies have demonstrated promising results of watch and wait (W&W) approaches in carefully selected patients with locally advanced rectal cancer who get a clinical complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT). This approach of organ- preservation helps patients avoid surgery and its related morbidity and mortality. nCRT will lead to the regression of the tumor cells and the uneven distribution of the residual tumor cells. The reliability of biopsy is still unsatisfactory in W&W strategy due to the high ratio of false negative cases. Therefore, the patients with negative histopathological assessment should also receive a strict follow-up. In the future, immune microenvironment and molecular markers, patient derived organoid, circulating tumor cells (CTCs) and circulating cell-free nucleic acids (cfDNA) may be helpful for screening and monitoring patients undergoing W&W.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery - 23(2020), 3 vom: 25. März, Seite 248-251 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Li, Z W [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 23.03.2020 Date Revised 23.03.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.3760/cma.j.cn.441530-20200224-00079 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307787257 |
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| 520 | |a Some studies have demonstrated promising results of watch and wait (W&W) approaches in carefully selected patients with locally advanced rectal cancer who get a clinical complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT). This approach of organ- preservation helps patients avoid surgery and its related morbidity and mortality. nCRT will lead to the regression of the tumor cells and the uneven distribution of the residual tumor cells. The reliability of biopsy is still unsatisfactory in W&W strategy due to the high ratio of false negative cases. Therefore, the patients with negative histopathological assessment should also receive a strict follow-up. In the future, immune microenvironment and molecular markers, patient derived organoid, circulating tumor cells (CTCs) and circulating cell-free nucleic acids (cfDNA) may be helpful for screening and monitoring patients undergoing W&W | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Pathological evaluation | |
| 650 | 4 | |a Rectal neoplasms | |
| 650 | 4 | |a Watch and wait strategy | |
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