Oxymetazoline, Mupirocin, Clotrimazole-Safe, Effective, Off-Label Agents for Tympanostomy Tube Care
OBJECTIVES: Only a few medications have a United States Food and Drug Administration indications for prevention and/or treatment of infections in patients with tympanic perforations or tympanostomy tubes. We examined 3 off-label agents that have become important in tympanostomy tube care hoping to demonstrate the effectiveness and safety of each in experimental assays and human application.
METHODS: Computerized literature review.
RESULTS: (1) Oxymetazoline nasal spray applied at the time of surgery is equivalent to fluoroquinolone ear drops in the prevention of early postsurgical otorrhea and tympanostomy tube occlusion at the first postoperative visit. (2) Topical mupirocin 2% ointment is effective alone or in combination with culture-directed systemic therapy for the treatment of tympanostomy tube otorrhea caused by community-acquired, methicillin-resistant Staphylococcus aureus. (3) Topical clotrimazole 1% cream is highly active against the common yeast and fungi that cause otomycosis. A single application after microscopic debridement will cure fungal tympanostomy tube otorrhea in most cases. None of these 3 agents is ototoxic in animal histological or physiological studies, and each has proved safe in long-term clinical use.
CONCLUSIONS: Oxymetazoline nasal spray, mupirocin ointment, and clotrimazole cream are safe and effective as off-label medications for tympanostomy tube care in children.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:99 |
|---|---|
| Enthalten in: |
Ear, nose, & throat journal - 99(2020), 1_suppl vom: 08. Nov., Seite 30S-34S |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Isaacson, Glenn [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
8VLN5B44ZY |
|---|
| Anmerkungen: |
Date Completed 13.08.2021 Date Revised 18.04.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1177/0145561320912885 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM307687147 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM307687147 | ||
| 003 | DE-627 | ||
| 005 | 20231225130116.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/0145561320912885 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1025.xml |
| 035 | |a (DE-627)NLM307687147 | ||
| 035 | |a (NLM)32182136 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Isaacson, Glenn |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Oxymetazoline, Mupirocin, Clotrimazole-Safe, Effective, Off-Label Agents for Tympanostomy Tube Care |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.08.2021 | ||
| 500 | |a Date Revised 18.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: Only a few medications have a United States Food and Drug Administration indications for prevention and/or treatment of infections in patients with tympanic perforations or tympanostomy tubes. We examined 3 off-label agents that have become important in tympanostomy tube care hoping to demonstrate the effectiveness and safety of each in experimental assays and human application | ||
| 520 | |a METHODS: Computerized literature review | ||
| 520 | |a RESULTS: (1) Oxymetazoline nasal spray applied at the time of surgery is equivalent to fluoroquinolone ear drops in the prevention of early postsurgical otorrhea and tympanostomy tube occlusion at the first postoperative visit. (2) Topical mupirocin 2% ointment is effective alone or in combination with culture-directed systemic therapy for the treatment of tympanostomy tube otorrhea caused by community-acquired, methicillin-resistant Staphylococcus aureus. (3) Topical clotrimazole 1% cream is highly active against the common yeast and fungi that cause otomycosis. A single application after microscopic debridement will cure fungal tympanostomy tube otorrhea in most cases. None of these 3 agents is ototoxic in animal histological or physiological studies, and each has proved safe in long-term clinical use | ||
| 520 | |a CONCLUSIONS: Oxymetazoline nasal spray, mupirocin ointment, and clotrimazole cream are safe and effective as off-label medications for tympanostomy tube care in children | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a clotrimazole | |
| 650 | 4 | |a mupirocin | |
| 650 | 4 | |a off-label medications | |
| 650 | 4 | |a otorrhea | |
| 650 | 4 | |a oxymetazoline | |
| 650 | 4 | |a tympanostomy tubes | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Nasal Sprays |2 NLM | |
| 650 | 7 | |a Oxymetazoline |2 NLM | |
| 650 | 7 | |a 8VLN5B44ZY |2 NLM | |
| 650 | 7 | |a Mupirocin |2 NLM | |
| 650 | 7 | |a D0GX863OA5 |2 NLM | |
| 650 | 7 | |a Clotrimazole |2 NLM | |
| 650 | 7 | |a G07GZ97H65 |2 NLM | |
| 773 | 0 | 8 | |i Enthalten in |t Ear, nose, & throat journal |d 1984 |g 99(2020), 1_suppl vom: 08. Nov., Seite 30S-34S |w (DE-627)NLM000261459 |x 1942-7522 |7 nnns |
| 773 | 1 | 8 | |g volume:99 |g year:2020 |g number:1_suppl |g day:08 |g month:11 |g pages:30S-34S |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/0145561320912885 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 99 |j 2020 |e 1_suppl |b 08 |c 11 |h 30S-34S | ||