Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses-to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:198 |
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| Enthalten in: |
Biological trace element research - 198(2020), 2 vom: 12. Dez., Seite 602-616 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rugiel, Marzena [VerfasserIn] |
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| Links: |
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| Themen: |
Biomarkers |
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| Anmerkungen: |
Date Completed 18.06.2021 Date Revised 18.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s12011-020-02104-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307546780 |
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| 520 | |a The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses-to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cluster and discriminant analysis | |
| 650 | 4 | |a Elemental analysis | |
| 650 | 4 | |a Iron oxide nanoparticles | |
| 650 | 4 | |a Multivariate methods | |
| 650 | 4 | |a Total reflection X-ray fluorescence microscopy | |
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| 700 | 1 | |a Matusiak, Katarzyna |e verfasserin |4 aut | |
| 700 | 1 | |a Setkowicz, Zuzanna |e verfasserin |4 aut | |
| 700 | 1 | |a Klodowski, Krzysztof |e verfasserin |4 aut | |
| 700 | 1 | |a Chwiej, Joanna |e verfasserin |4 aut | |
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