Antioxidant Approach as a Cardioprotective Strategy in Chemotherapy-Induced Cardiotoxicity
Significance: Chemotherapy-induced cardiotoxicity (CTX) has been associated with redox signaling imbalance. In fact, redox reactions are crucial for normal heart physiology, whereas excessive oxidative stress can cause cardiomyocyte structural damage. Recent Advances: An antioxidant approach as a cardioprotective strategy in this setting has shown encouraging results in preventing anticancer drug-induced CTX. Critical Issues: In fact, traditional heart failure drugs as well as many other compounds and nonpharmacological strategies, with a partial effect in reducing oxidative stress, have been shown to counterbalance chemotherapy-induced CTX in this setting to some extent. Future Directions: Given the various pathways of toxicity involved in different chemotherapeutic schemes, interactions with redox balance need to be fine-tuned and a personalized cardioprotective approach seems to be required.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Antioxidants & redox signaling - 34(2021), 7 vom: 01. März, Seite 572-588 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cadeddu Dessalvi, Christian [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents |
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| Anmerkungen: |
Date Completed 11.10.2021 Date Revised 11.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1089/ars.2020.8055 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM30739476X |
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| 520 | |a Significance: Chemotherapy-induced cardiotoxicity (CTX) has been associated with redox signaling imbalance. In fact, redox reactions are crucial for normal heart physiology, whereas excessive oxidative stress can cause cardiomyocyte structural damage. Recent Advances: An antioxidant approach as a cardioprotective strategy in this setting has shown encouraging results in preventing anticancer drug-induced CTX. Critical Issues: In fact, traditional heart failure drugs as well as many other compounds and nonpharmacological strategies, with a partial effect in reducing oxidative stress, have been shown to counterbalance chemotherapy-induced CTX in this setting to some extent. Future Directions: Given the various pathways of toxicity involved in different chemotherapeutic schemes, interactions with redox balance need to be fine-tuned and a personalized cardioprotective approach seems to be required | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Madeddu, Clelia |e verfasserin |4 aut | |
| 700 | 1 | |a Cugusi, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Santoro, Ciro |e verfasserin |4 aut | |
| 700 | 1 | |a López-Fernández, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Galderisi, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Mercuro, Giuseppe |e verfasserin |4 aut | |
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