Blog
Feedback
schliessen

Filtern

 

Bibliotheken

Logo der Bibliothek

Logo FID Pharmazie PubPharm Discovery System Universitätsbibliothek Braunschweig Institut für Informationssysteme

Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea : the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR

© 2020 The Korean Academy of Medical Sciences.

Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed

Comment in: J Korean Med Sci. 2020 Feb 24;35(7):e88. - PMID 32080992
Year of Publication: 2020
Contained in: Journal of Korean medical science Vol. 35, No. 6 (2020), p. e79
All journal articles: Search for all articles in this journal
Language: English
Contributors: Lim, Jaegyun | Author
Jeon, Seunghyun
Shin, Hyun Young
Kim, Moon Jung
Seong, Yu Min
Lee, Wang Jun
Choe, Kang Won
Kang, Yu Min
Lee, Baeckseung
Park, Sang Joon
Full text access:
Electronic availability is being checked...
Links: Full Text (dx.doi.org)
Keywords: 2494G1JF75
COVID-19
Case Reports
Coronavirus
Cytochrome P-450 CYP3A Inhibitors
Journal Article
Lopinavir
O3J8G9O825
Pneumonia
Real-Time Reverse-Transcriptase Polymerase Chain Reaction
Ritonavir
Tertiary Infection
lopinavir-ritonavir drug combination
Additional Keywords: *Coronavirus Infections
*Cytochrome P-450 CYP3A Inhibitors
*Lopinavir
*Pneumonia
*Pneumonia, Viral
*Ritonavir
Betacoronavirus
China
Drug Combinations
Humans
Male
Middle Aged
Real-Time Polymerase Chain Reaction
Republic of Korea
Viral Load
ISSN: 1598-6357
Note: Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Notes: Date Completed 16.03.2020
Date Revised 13.04.2020
published: Electronic
CommentIn: J Korean Med Sci. 2020 Feb 24;35(7):e88. - PMID 32080992
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PMID:
    32056407
Physical Description: Online-Ressource
ID (e.g. DOI, URN): 10.3346/jkms.2020.35.e79
more publication details ...

Associated Publications

  • Associated records are being queried...
more (+)
Internes Format
LEADER 04802nma a2201021 c 4500
001 NLM307274705
003 DE-601
005 20200610213703.0
007 cr uuu---uuuuu
008 200221s2020 000 0 eng d
024 7 |a 10.3346/jkms.2020.35.e79  |2 doi 
028 5 2 |a pubmed20n1227.xml 
035 |a (DE-599)NLM32056407 
040 |b ger  |c GBVCP 
041 0 |a eng 
100 1 |a Lim, Jaegyun 
245 1 0 |a Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea  |h Elektronische Ressource  |b the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR 
300 |a Online-Ressource 
500 |a Date Completed 16.03.2020 
500 |a Date Revised 13.04.2020 
500 |a published: Electronic 
500 |a CommentIn: J Korean Med Sci. 2020 Feb 24;35(7):e88. - PMID 32080992 
500 |a Citation Status MEDLINE 
500 |a Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine 
520 |a © 2020 The Korean Academy of Medical Sciences. 
520 |a Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed 
611 2 7 |a Case Reports  |2 gnd 
611 2 7 |a Journal Article  |2 gnd 
653 2 |a Betacoronavirus  |6 D000073640  |a genetics  |6 Q000235 
653 2 |a China  |6 D002681 
653 2 |a *Coronavirus Infections  |6 D018352  |a complications  |6 Q000150  |a drug therapy  |6 Q000188  |a transmission  |6 Q000635 
653 2 |a *Cytochrome P-450 CYP3A Inhibitors  |6 D065692  |a therapeutic use  |6 Q000627 
653 2 |a Drug Combinations  |6 D004338 
653 2 |a Humans  |6 D006801 
653 2 |a *Lopinavir  |6 D061466  |a therapeutic use  |6 Q000627 
653 2 |a Male  |6 D008297 
653 2 |a Middle Aged  |6 D008875 
653 2 |a *Pneumonia  |6 D011014  |a diagnosis  |6 Q000175  |a drug therapy  |6 Q000188  |a etiology  |6 Q000209 
653 2 |a *Pneumonia, Viral  |6 D011024  |a complications  |6 Q000150  |a drug therapy  |6 Q000188  |a transmission  |6 Q000635 
653 2 |a Real-Time Polymerase Chain Reaction  |6 D060888 
653 2 |a Republic of Korea  |6 D056910 
653 2 |a *Ritonavir  |6 D019438  |a therapeutic use  |6 Q000627 
653 2 |a Viral Load  |6 D019562 
655 7 |a COVID-19  |2 gnd 
655 7 |a Coronavirus  |2 gnd 
655 7 |a Pneumonia  |2 gnd 
655 7 |a Real-Time Reverse-Transcriptase Polymerase Chain Reaction  |2 gnd 
655 7 |a Tertiary Infection  |2 gnd 
655 7 |a Viral Load  |2 gnd 
655 7 |a Cytochrome P-450 CYP3A Inhibitors  |2 gnd 
655 7 |a Drug Combinations  |2 gnd 
655 7 |a lopinavir-ritonavir drug combination  |2 gnd 
655 7 |a Lopinavir  |2 gnd 
655 7 |a 2494G1JF75  |2 gnd 
655 7 |a Ritonavir  |2 gnd 
655 7 |a O3J8G9O825  |2 gnd 
689 0 0 |A f  |a Case Reports 
689 0 1 |A f  |a Journal Article 
689 0 |5 DE-601 
689 1 0 |a COVID-19 
689 1 1 |a Coronavirus 
689 1 2 |a Pneumonia 
689 1 3 |a Real-Time Reverse-Transcriptase Polymerase Chain Reaction 
689 1 4 |a Tertiary Infection 
689 1 5 |a Viral Load 
689 1 |5 DE-601 
689 2 0 |a Cytochrome P-450 CYP3A Inhibitors 
689 2 1 |a Drug Combinations 
689 2 2 |a lopinavir-ritonavir drug combination 
689 2 3 |a Lopinavir 
689 2 4 |A r  |a 2494G1JF75 
689 2 5 |a Ritonavir 
689 2 6 |A r  |a O3J8G9O825 
689 2 |5 DE-601 
700 1 |a Jeon, Seunghyun 
700 1 |a Shin, Hyun Young 
700 1 |a Kim, Moon Jung 
700 1 |a Seong, Yu Min 
700 1 |a Lee, Wang Jun 
700 1 |a Choe, Kang Won 
700 1 |a Kang, Yu Min 
700 1 |a Lee, Baeckseung 
700 1 |a Park, Sang Joon 
773 0 8 |i in  |t Journal of Korean medical science  |g Vol. 35, No. 6 (2020), p. e79  |q 35:6<e79  |w (DE-601)NLM012649392  |x 1598-6357 
856 4 1 |u http://dx.doi.org/10.3346/jkms.2020.35.e79  |3 Volltext 
912 |a GBV_NLM 
951 |a AR 
952 |d 35  |j 2020  |e 6  |b 17  |c 02  |h e79