OM-85 BV for primary prevention of recurrent airway infections : a pilot randomized, double-blind, placebo-controlled study

OBJECTIVE: To compare the frequency of respiratory tract infections in children treated with OM-85 BV and placebo during the 3-month therapy period, and observation for a further 3 months after treatment.

METHODS: A randomized, double-blind, placebo-controlled trial was conducted with 54 children (6 months to 5 years old) with no past history of recurrent respiratory infections attending daycare center. Family members were instructed to administer one capsule per day for 10 consecutive days, for 3 months of OM-85 BV or placebo. Telephone interviews were conducted every 30 days.

RESULTS: There was no significant difference in the number of respiratory infections between the groups. The mean number of respiratory tract infection in the OM-85 BV Group in the first 3 months was 0.92±0.87, and in the Placebo Group was 0.74±1.02, and at 6 months it was 1.62±1.47 and 1.03±1.34, respectively.

CONCLUSION: OM-85 BV was not effective in the primary prevention of respiratory tract infections. Although most authors recommend the use of this immunostimulant in children with a history of recurrent respiratory infections, more studies are needed to define its usefulness in the primary prevention of respiratory infections in healthy children exposed to few risk factors.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:18

Enthalten in:

Einstein (Sao Paulo, Brazil) - 18(2020) vom: 02., Seite eAO5262

Sprache:

Englisch

Beteiligte Personen:

Souza, Fátima Cleonice de [VerfasserIn]
Mocellin, Magáli [VerfasserIn]
Ongaratto, Renata [VerfasserIn]
Leitão, Lidiane Alves de Azeredo [VerfasserIn]
Friedrich, Frederico Orlando [VerfasserIn]
Silveira, Victória d'A [VerfasserIn]
Scotta, Marcelo Comerlato [VerfasserIn]
Pitrez, Paulo Márcio [VerfasserIn]
Pinto, Leonardo Araújo [VerfasserIn]

Links:

Volltext

Themen:

Adjuvants, Immunologic
Broncho-Vaxom
Cell Extracts
Journal Article
Randomized Controlled Trial
Tobacco Smoke Pollution

Anmerkungen:

Date Completed 30.03.2020

Date Revised 30.03.2020

published: Electronic-eCollection

Citation Status MEDLINE

doi:

10.31744/einstein_journal/2020AO5262

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM307216179