The endothelial barrier and cancer metastasis : Does the protective facet of platelet function matter?
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved..
Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer-related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet-dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:176 |
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| Enthalten in: |
Biochemical pharmacology - 176(2020) vom: 23. Juni, Seite 113886 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Smeda, Marta [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer metastasis |
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| Anmerkungen: |
Date Completed 26.10.2020 Date Revised 26.10.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bcp.2020.113886 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM307059847 |
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| 245 | 1 | 4 | |a The endothelial barrier and cancer metastasis |b Does the protective facet of platelet function matter? |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer-related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet-dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cancer metastasis | |
| 650 | 4 | |a Inflammation-associated hemostasis | |
| 650 | 4 | |a Platelet inhibition | |
| 650 | 4 | |a Platelet-cancer cell interaction | |
| 700 | 1 | |a Przyborowski, Kamil |e verfasserin |4 aut | |
| 700 | 1 | |a Stojak, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Chlopicki, Stefan |e verfasserin |4 aut | |
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