The Congenital Heart Disease Brain : Prenatal Considerations for Perioperative Neurocritical Care
Copyright © 2020 Elsevier Inc. All rights reserved..
Altered brain development has been highlighted as an important contributor to adverse neurodevelopmental outcomes in children with congenital heart disease. Abnormalities begin prenatally and include micro- and macrostructural disturbances that lead to an altered trajectory of brain growth throughout gestation. Recent progress in fetal imaging has improved understanding of the neurobiological mechanisms and risk factors for impaired fetal brain development. The impact of the prenatal environment on postnatal neurological care has also gained increased focus. This review summarizes current data on the timing and pattern of altered prenatal brain development in congenital heart disease, the potential mechanisms of these abnormalities, and the association with perioperative neurological complications.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
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Enthalten in: |
Pediatric neurology - 108(2020) vom: 24. Juli, Seite 23-30 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ortinau, Cynthia M [VerfasserIn] |
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Links: |
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Themen: |
Brain |
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Anmerkungen: |
Date Completed 02.06.2021 Date Revised 02.07.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.pediatrneurol.2020.01.002 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM306994224 |
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520 | |a Altered brain development has been highlighted as an important contributor to adverse neurodevelopmental outcomes in children with congenital heart disease. Abnormalities begin prenatally and include micro- and macrostructural disturbances that lead to an altered trajectory of brain growth throughout gestation. Recent progress in fetal imaging has improved understanding of the neurobiological mechanisms and risk factors for impaired fetal brain development. The impact of the prenatal environment on postnatal neurological care has also gained increased focus. This review summarizes current data on the timing and pattern of altered prenatal brain development in congenital heart disease, the potential mechanisms of these abnormalities, and the association with perioperative neurological complications | ||
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