Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs
© 2017 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V..
We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (NFP) and midazolam (MDZ), in male Wistar rats. Oral administration of GFJ 90 min before the intraduodenal administration of NFP or MDZ increased the area under the concentration-time curves (AUCs) of NFP and MDZ by 32.4% and 89.4%, respectively. TJ increased MDZ blood concentrations and AUC after intraduodenal MDZ administration; however, it had no effect on NFP. When MDZ and NFP were intravenously administered, GFJ significantly increased the AUC of MDZ, but only slightly increased that of NFP. In contrast, TJ only slightly increased the AUC of MDZ. These results suggest that, similar to GFJ, TJ influences the pharmacokinetics of CYP3A4-substrate drugs; however, it may be a drug-dependent partial effect.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Asian journal of pharmaceutical sciences - 12(2017), 5 vom: 14. Sept., Seite 464-469 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ohkubo, Atsuko [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 28.09.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.ajps.2017.05.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM30696676X |
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| 245 | 1 | 0 | |a Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs |
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| 500 | |a Date Revised 28.09.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2017 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. | ||
| 520 | |a We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (NFP) and midazolam (MDZ), in male Wistar rats. Oral administration of GFJ 90 min before the intraduodenal administration of NFP or MDZ increased the area under the concentration-time curves (AUCs) of NFP and MDZ by 32.4% and 89.4%, respectively. TJ increased MDZ blood concentrations and AUC after intraduodenal MDZ administration; however, it had no effect on NFP. When MDZ and NFP were intravenously administered, GFJ significantly increased the AUC of MDZ, but only slightly increased that of NFP. In contrast, TJ only slightly increased the AUC of MDZ. These results suggest that, similar to GFJ, TJ influences the pharmacokinetics of CYP3A4-substrate drugs; however, it may be a drug-dependent partial effect | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 13-oxo-ODA, 13-oxo-9,11-octadecadenoic acid | |
| 650 | 4 | |a 9-oxo-ODA, 9-oxo-10,12-octadecadienoic acid | |
| 650 | 4 | |a AUC, area under the concentration–time curve | |
| 650 | 4 | |a CYP, cytochrome P450 | |
| 650 | 4 | |a Food–drug interactions | |
| 650 | 4 | |a GFJ, grapefruit juice | |
| 650 | 4 | |a Grapefruit juice | |
| 650 | 4 | |a MDZ, midazolam | |
| 650 | 4 | |a Midazolam | |
| 650 | 4 | |a NFP, nifedipine | |
| 650 | 4 | |a Nifedipine | |
| 650 | 4 | |a Pharmacokinetic interactions | |
| 650 | 4 | |a TJ, tomato juice | |
| 650 | 4 | |a Tomato juice | |
| 700 | 1 | |a Chida, Tomomi |e verfasserin |4 aut | |
| 700 | 1 | |a Kikuchi, Hidetomo |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuda, Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Sunaga, Katsuyoshi |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:12 |g year:2017 |g number:5 |g day:14 |g month:09 |g pages:464-469 |
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