Topical treatment strategies to manipulate human skin pigmentation

Copyright © 2020. Published by Elsevier B.V..

Skin pigmentation is a result of melanin produced by melanocytes in the epidermis. Melanocyte activity, along with the type and distribution of melanins, is the main driver for diversity of skin pigmentation. Dark melanin acts to protect against the deleterious effects of ultraviolet (UV) radiation, including photo-aging and skin cancer formation. In turn, UV radiation activates skin melanocytes to induce further pigmentation (i.e., "tanning pathway"). The well-characterized MSH/MC1R-cAMP-MITF pathway regulates UV-induced melanization. Pharmacologic activation of this pathway ("sunless tanning") represents a potential strategy for skin cancer prevention, particularly in those with light skin or the "red hair" phenotype who tan poorly after UV exposure due to MC1R inactivating polymorphisms. Skin hyperpigmentation can also occur as a result of inflammatory processes and dermatological disorders such as melasma. While primarily of cosmetic concern, these conditions can dramatically impact quality of life of affected patients. Several topical agents are utilized to treat skin pigmentation disorders. Here, we review melanogenesis induced by UV exposure and the agents that target this pathway.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:153

Enthalten in:

Advanced drug delivery reviews - 153(2020) vom: 01. Jan., Seite 65-71

Sprache:

Englisch

Beteiligte Personen:

Rachmin, Inbal [VerfasserIn]
Ostrowski, Stephen M [VerfasserIn]
Weng, Qing Yu [VerfasserIn]
Fisher, David E [VerfasserIn]

Links:

Volltext

Themen:

12627-86-0
CAMP
Cyclic AMP
Dermatologic Agents
E0399OZS9N
EC 2.7.-
Eumelanin
Journal Article
MITF
Melanins
Melanocytes
Pheomelanin
Pigmentation
Protein Kinases
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Systematic Review

Anmerkungen:

Date Completed 08.09.2021

Date Revised 08.09.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.addr.2020.02.002

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM306849887