A core-shell multi-drug platform to improve gastrointestinal tract microbial health using 3D printing

Improving the proliferation of probiotics (ca. Bifidobacterium) and inhibiting the growth of pathogenic bacteria (ca. Escherichia coli) is crucial for human health. This study demonstrates the fabrication of core-shell structure fibers using electrohydrodynamic 3D printing to help improve gastrointestinal tract microbial content. These fibers have various geometries and are capable of encapsulating stachyose into cellulose acetate (shell layer) and loading proteoglycan into polyacrylic resin II (core layer). The impact of membrane geometry on drug release behavior and the effect of exchanging the loading site on physicochemical properties of the resulting fibers were studied. The printed fibrous membranes possess a biphasic drug release profile in simulated intestinal fluid with a burst release within the first 12 h and a slower sustained release up to 72 h. The speed order priority for drug release rate of the printed membrane was whole-circle > semi-circle > square. Moreover, the membranes exhibit good biocompatibility on L929 cells and excellent improvement effects on Bifidobacterium bifidum, combining inhibition effects on Escherichia coli. In summary, the dual-drug fibrous membranes presented here and their precision-fabricated patterns pave a new direction for improving the gastrointestinal tract microbial ecosystem health in the human body.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

Biofabrication - 12(2020), 2 vom: 13. März, Seite 025026

Sprache:

Englisch

Beteiligte Personen:

Zhu, Li-Fang [VerfasserIn]
Chen, Xing [VerfasserIn]
Ahmad, Zeeshan [VerfasserIn]
Peng, Yu [VerfasserIn]
Chang, Ming-Wei [VerfasserIn]

Links:

Volltext

Themen:

25VX64653N
3J2P07GVB6
4Q93RCW27E
9004-34-6
Acetylcellulose
Acrylic Resins
Biocompatible Materials
Carbopol 940
Cellulose
Drug Carriers
Journal Article
Oligosaccharides
Proteoglycans
Research Support, Non-U.S. Gov't
Stachyose

Anmerkungen:

Date Completed 17.12.2020

Date Revised 17.12.2020

published: Electronic

Citation Status MEDLINE

doi:

10.1088/1758-5090/ab782c

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM306776006