Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia
Copyright © 2020 Marco Ciacciarelli et al..
Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:2020 |
---|---|
Enthalten in: |
Case reports in endocrinology - 2020(2020) vom: 31., Seite 4239679 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ciacciarelli, Marco [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Revised 28.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1155/2020/4239679 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM306762420 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM306762420 | ||
003 | DE-627 | ||
005 | 20231225124102.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1155/2020/4239679 |2 doi | |
028 | 5 | 2 | |a pubmed24n1022.xml |
035 | |a (DE-627)NLM306762420 | ||
035 | |a (NLM)32082648 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Ciacciarelli, Marco |e verfasserin |4 aut | |
245 | 1 | 0 | |a Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 28.09.2020 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a Copyright © 2020 Marco Ciacciarelli et al. | ||
520 | |a Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure | ||
650 | 4 | |a Case Reports | |
700 | 1 | |a Caruso, Gianluca |e verfasserin |4 aut | |
700 | 1 | |a Rengo, Marco |e verfasserin |4 aut | |
700 | 1 | |a Maceroni, Piero |e verfasserin |4 aut | |
700 | 1 | |a Misurale, Carmen |e verfasserin |4 aut | |
700 | 1 | |a D'Armiento, Eleonora |e verfasserin |4 aut | |
700 | 1 | |a Polidoro, Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Napoli, Cristina |e verfasserin |4 aut | |
700 | 1 | |a Lombardini, Alberto |e verfasserin |4 aut | |
700 | 1 | |a Ceratti, Umberto |e verfasserin |4 aut | |
700 | 1 | |a Colunga Biancatelli, Ruben Manuel Luciano |e verfasserin |4 aut | |
700 | 1 | |a Calvosa, Leonardo |e verfasserin |4 aut | |
700 | 1 | |a Milanese, Romina |e verfasserin |4 aut | |
700 | 1 | |a Ferri, Sonia |e verfasserin |4 aut | |
700 | 1 | |a Massaro, Teresa |e verfasserin |4 aut | |
700 | 1 | |a Lorusso, Andrea |e verfasserin |4 aut | |
700 | 1 | |a Sorrentino, Veronica |e verfasserin |4 aut | |
700 | 1 | |a Petrozza, Vincenzo |e verfasserin |4 aut | |
700 | 1 | |a Iuliano, Luigi |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Case reports in endocrinology |d 2011 |g 2020(2020) vom: 31., Seite 4239679 |w (DE-627)NLM22061475X |x 2090-6501 |7 nnns |
773 | 1 | 8 | |g volume:2020 |g year:2020 |g day:31 |g pages:4239679 |
856 | 4 | 0 | |u http://dx.doi.org/10.1155/2020/4239679 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 2020 |j 2020 |b 31 |h 4239679 |