Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia

Copyright © 2020 Marco Ciacciarelli et al..

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:2020

Enthalten in:

Case reports in endocrinology - 2020(2020) vom: 31., Seite 4239679

Sprache:

Englisch

Beteiligte Personen:

Ciacciarelli, Marco [VerfasserIn]
Caruso, Gianluca [VerfasserIn]
Rengo, Marco [VerfasserIn]
Maceroni, Piero [VerfasserIn]
Misurale, Carmen [VerfasserIn]
D'Armiento, Eleonora [VerfasserIn]
Polidoro, Alessandro [VerfasserIn]
Napoli, Cristina [VerfasserIn]
Lombardini, Alberto [VerfasserIn]
Ceratti, Umberto [VerfasserIn]
Colunga Biancatelli, Ruben Manuel Luciano [VerfasserIn]
Calvosa, Leonardo [VerfasserIn]
Milanese, Romina [VerfasserIn]
Ferri, Sonia [VerfasserIn]
Massaro, Teresa [VerfasserIn]
Lorusso, Andrea [VerfasserIn]
Sorrentino, Veronica [VerfasserIn]
Petrozza, Vincenzo [VerfasserIn]
Iuliano, Luigi [VerfasserIn]

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Themen:

Case Reports

Anmerkungen:

Date Revised 28.09.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.1155/2020/4239679

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM306762420