Prediagnosis dietary pattern and survival in patients with multiple myeloma
© 2020 UICC..
Inflammation and endogenous growth factors are important in multiple myeloma (MM) pathogenesis. Although diets that modulate these biologic pathways may influence MM patient survival, studies have not examined the association of dietary patterns with MM survival. We conducted pooled prospective survival analyses of 423 MM patients from the Nurses' Health Study (1986-2016) and the Health Professionals Follow-up Study (1988-2016) using Cox regression models. We used data from repeated food frequency questionnaires (FFQ) to compute dietary patterns as of the last prediagnosis FFQ, including the Alternate Healthy Eating Index (AHEI)-2010, alternate Mediterranean Diet, Dietary Approaches to Stop Hypertension, Prudent, Western and empirical dietary inflammatory patterns and empirical dietary indices for insulin resistance and hyperinsulinemia. During follow-up, we documented 295 MM-related deaths among 345 total deaths. MM-specific mortality was 15-24% lower per one standard deviation (SD) increase (e.g., toward healthier habits) in favorable dietary pattern scores. For example, the multivariable-adjusted hazard ratio [HR] and 95% confidence interval [CI] per 1-SD increase in AHEI-2010 score were 0.76, 0.67-0.87 (p < 0.001). In contrast, MM-specific mortality was 16-24% higher per 1-SD increase (e.g., toward less healthy habits) in "unhealthy" diet scores; for example, the multivariable-adjusted HR, 95% CI per 1-SD increase in Western pattern score were 1.24, 1.07-1.44 (p = 0.005). Associations were similar for all-cause mortality. In conclusion, our consistent findings for multiple dietary patterns provide the first evidence that MM patients with healthier prediagnosis dietary habits may have longer survival than those with less healthy diets.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:147 |
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| Enthalten in: |
International journal of cancer - 147(2020), 7 vom: 01. Okt., Seite 1823-1830 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Dong Hoon [VerfasserIn] |
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| Links: |
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| Themen: |
Dietary pattern |
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| Anmerkungen: |
Date Completed 08.04.2021 Date Revised 19.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/ijc.32928 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM306612801 |
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| 520 | |a Inflammation and endogenous growth factors are important in multiple myeloma (MM) pathogenesis. Although diets that modulate these biologic pathways may influence MM patient survival, studies have not examined the association of dietary patterns with MM survival. We conducted pooled prospective survival analyses of 423 MM patients from the Nurses' Health Study (1986-2016) and the Health Professionals Follow-up Study (1988-2016) using Cox regression models. We used data from repeated food frequency questionnaires (FFQ) to compute dietary patterns as of the last prediagnosis FFQ, including the Alternate Healthy Eating Index (AHEI)-2010, alternate Mediterranean Diet, Dietary Approaches to Stop Hypertension, Prudent, Western and empirical dietary inflammatory patterns and empirical dietary indices for insulin resistance and hyperinsulinemia. During follow-up, we documented 295 MM-related deaths among 345 total deaths. MM-specific mortality was 15-24% lower per one standard deviation (SD) increase (e.g., toward healthier habits) in favorable dietary pattern scores. For example, the multivariable-adjusted hazard ratio [HR] and 95% confidence interval [CI] per 1-SD increase in AHEI-2010 score were 0.76, 0.67-0.87 (p < 0.001). In contrast, MM-specific mortality was 16-24% higher per 1-SD increase (e.g., toward less healthy habits) in "unhealthy" diet scores; for example, the multivariable-adjusted HR, 95% CI per 1-SD increase in Western pattern score were 1.24, 1.07-1.44 (p = 0.005). Associations were similar for all-cause mortality. In conclusion, our consistent findings for multiple dietary patterns provide the first evidence that MM patients with healthier prediagnosis dietary habits may have longer survival than those with less healthy diets | ||
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| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Mediterranean diet | |
| 650 | 4 | |a Western diet | |
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| 650 | 4 | |a healthy eating index | |
| 650 | 4 | |a multiple myeloma | |
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| 700 | 1 | |a Fung, Teresa T |e verfasserin |4 aut | |
| 700 | 1 | |a Tabung, Fred K |e verfasserin |4 aut | |
| 700 | 1 | |a Marinac, Catherine R |e verfasserin |4 aut | |
| 700 | 1 | |a Devore, Elizabeth E |e verfasserin |4 aut | |
| 700 | 1 | |a Rosner, Bernard A |e verfasserin |4 aut | |
| 700 | 1 | |a Ghobrial, Irene M |e verfasserin |4 aut | |
| 700 | 1 | |a Colditz, Graham A |e verfasserin |4 aut | |
| 700 | 1 | |a Giovannucci, Edward L |e verfasserin |4 aut | |
| 700 | 1 | |a Birmann, Brenda M |e verfasserin |4 aut | |
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