Detection of the usual interstitial pneumonia pattern in chest CT : effect of computer-aided diagnosis on radiologist diagnostic performance
BACKGROUND: Anti-fibrotic drugs for interstitial pulmonary fibrosis (IPF) have been developed. Physicians are becoming increasingly aware of the need for better diagnosis of IPF.
PURPOSE: To evaluate whether a computer-aided system can improve the diagnostic performance of general radiologists in detecting the usual interstitial pneumonia (UIP) pattern on computed tomography (CT).
MATERIAL AND METHODS: We included 60 CT datasets from 30 patients with IPF and 30 with idiopathic fibrosing non-specific interstitial pneumonia (fNSIP), all diagnosed by a multidisciplinary diagnosis (MDD) procedure that included surgical biopsy. We analyzed the CT data using a computer-aided system (Gaussian histogram normalized correlation: GHNC). Five general radiologists with <6 years of experience each interpreted these CT scans with and without the GHNC results. We compared the likelihoods of a UIP-pattern diagnosis with the likelihood of the same diagnosis by MDD using the average area under the curve (AUC) of the receiver operating characteristics (ROC). We also evaluated the association between the radiologists' diagnosis and survival using the Kaplan-Meier method.
RESULTS: In the ROC analysis, the AUC increased significantly from 0.731 without GHNC to 0.829 with GHNC (P = 0.0396). The diagnosis without GHNC was not significantly associated with survival for any radiologist, but the UIP diagnosis with GHNC was significantly associated with a worse prognosis for four out of five radiologists.
CONCLUSION: The computer-aided system could increase the confidence level of UIP-pattern diagnosis by non-expert radiologists.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
---|---|
Enthalten in: |
Acta radiologica (Stockholm, Sweden : 1987) - 65(2024), 3 vom: 15. März, Seite 259-266 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Fujita, Ryo [VerfasserIn] |
---|
Links: |
---|
Themen: |
Computer-aided diagnosis |
---|
Anmerkungen: |
Date Completed 26.03.2024 Date Revised 26.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1177/0284185120902393 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM306589958 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM306589958 | ||
003 | DE-627 | ||
005 | 20240326234642.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1177/0284185120902393 |2 doi | |
028 | 5 | 2 | |a pubmed24n1348.xml |
035 | |a (DE-627)NLM306589958 | ||
035 | |a (NLM)32064889 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Fujita, Ryo |e verfasserin |4 aut | |
245 | 1 | 0 | |a Detection of the usual interstitial pneumonia pattern in chest CT |b effect of computer-aided diagnosis on radiologist diagnostic performance |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 26.03.2024 | ||
500 | |a Date Revised 26.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a BACKGROUND: Anti-fibrotic drugs for interstitial pulmonary fibrosis (IPF) have been developed. Physicians are becoming increasingly aware of the need for better diagnosis of IPF | ||
520 | |a PURPOSE: To evaluate whether a computer-aided system can improve the diagnostic performance of general radiologists in detecting the usual interstitial pneumonia (UIP) pattern on computed tomography (CT) | ||
520 | |a MATERIAL AND METHODS: We included 60 CT datasets from 30 patients with IPF and 30 with idiopathic fibrosing non-specific interstitial pneumonia (fNSIP), all diagnosed by a multidisciplinary diagnosis (MDD) procedure that included surgical biopsy. We analyzed the CT data using a computer-aided system (Gaussian histogram normalized correlation: GHNC). Five general radiologists with <6 years of experience each interpreted these CT scans with and without the GHNC results. We compared the likelihoods of a UIP-pattern diagnosis with the likelihood of the same diagnosis by MDD using the average area under the curve (AUC) of the receiver operating characteristics (ROC). We also evaluated the association between the radiologists' diagnosis and survival using the Kaplan-Meier method | ||
520 | |a RESULTS: In the ROC analysis, the AUC increased significantly from 0.731 without GHNC to 0.829 with GHNC (P = 0.0396). The diagnosis without GHNC was not significantly associated with survival for any radiologist, but the UIP diagnosis with GHNC was significantly associated with a worse prognosis for four out of five radiologists | ||
520 | |a CONCLUSION: The computer-aided system could increase the confidence level of UIP-pattern diagnosis by non-expert radiologists | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Computer-aided diagnosis | |
650 | 4 | |a idiopathic pulmonary fibrosis | |
650 | 4 | |a interstitial lung diseases | |
650 | 4 | |a lung | |
650 | 4 | |a multidetector computed tomography | |
700 | 1 | |a Iwasawa, Tae |e verfasserin |4 aut | |
700 | 1 | |a Aoki, Takatoshi |e verfasserin |4 aut | |
700 | 1 | |a Iwao, Yuma |e verfasserin |4 aut | |
700 | 1 | |a Ogura, Takashi |e verfasserin |4 aut | |
700 | 1 | |a Utsunomiya, Daisuke |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Acta radiologica (Stockholm, Sweden : 1987) |d 1996 |g 65(2024), 3 vom: 15. März, Seite 259-266 |w (DE-627)NLM013028316 |x 1600-0455 |7 nnns |
773 | 1 | 8 | |g volume:65 |g year:2024 |g number:3 |g day:15 |g month:03 |g pages:259-266 |
856 | 4 | 0 | |u http://dx.doi.org/10.1177/0284185120902393 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 65 |j 2024 |e 3 |b 15 |c 03 |h 259-266 |