The value of diffusion weighted imaging and apparent diffusion coefficient in primary Osteogenic and Ewing sarcomas for the monitoring of response to treatment : Initial experience
Copyright © 2020 Elsevier B.V. All rights reserved..
PURPOSE: To assess the value of using Apparent Diffusion Coefficient (ADC) mapping in Diffusion Weighted Imaging (DWI) when monitoring treatment response in pediatric Osteogenic and Ewing sarcomas and to correlate with level of necrosis on post-surgical excision pathology.
METHOD: This retrospective study includes 7 Osteosarcoma and 8 Ewing sarcoma patients. Pre-treatment and post-treatment focal MRIs were evaluated for ADC values, tumor volumes and variability of both measurements. We also compared the measurement between Ewing and Osteosarcoma groups, as well as between good (=/>90 % necrosis post-excision) and poor (<90 % necrosis post-excision) responders.
RESULTS: All measurements except Maximum ADC (p = 0.20) showed a statistically significant difference when comparing them before and after treatment. When we segregated our population according to pathologic complete response, there was no difference in ADC measurements, volumetric measurements or either variability between good (8 Patients) and poor responders (7 Patients). When comparing the before-after changes in our measurement between the Ewing sarcoma and Osteosarcoma cases, there was no significant difference in the change between pre and post treatment (Δ) Mean or Maximum ADC, or in Δtumor-volume when measured on STIR or SPIR T1 post-contrast sequences. Only the ΔMinimum-ADC showed a statistically significant difference (p < 0.02) in this group.
CONCLUSIONS: ADC can potentially reflect cellular changes associated with chemotherapy use, reflecting a response to treatment. However, quantitative use of those parameters to dictate a change in management, treatment regimen or chemotherapy dose in order to target a good response (>/ = 90 % necrosis post-excision) needs further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:124 |
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| Enthalten in: |
European journal of radiology - 124(2020) vom: 28. März, Seite 108855 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Asmar, Karl [VerfasserIn] |
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| Links: |
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| Themen: |
Apparent Diffusion Coefficient (ADC) |
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| Anmerkungen: |
Date Completed 14.10.2020 Date Revised 14.10.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejrad.2020.108855 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM306134942 |
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| 100 | 1 | |a Asmar, Karl |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The value of diffusion weighted imaging and apparent diffusion coefficient in primary Osteogenic and Ewing sarcomas for the monitoring of response to treatment |b Initial experience |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 14.10.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier B.V. All rights reserved. | ||
| 520 | |a PURPOSE: To assess the value of using Apparent Diffusion Coefficient (ADC) mapping in Diffusion Weighted Imaging (DWI) when monitoring treatment response in pediatric Osteogenic and Ewing sarcomas and to correlate with level of necrosis on post-surgical excision pathology | ||
| 520 | |a METHOD: This retrospective study includes 7 Osteosarcoma and 8 Ewing sarcoma patients. Pre-treatment and post-treatment focal MRIs were evaluated for ADC values, tumor volumes and variability of both measurements. We also compared the measurement between Ewing and Osteosarcoma groups, as well as between good (=/>90 % necrosis post-excision) and poor (<90 % necrosis post-excision) responders | ||
| 520 | |a RESULTS: All measurements except Maximum ADC (p = 0.20) showed a statistically significant difference when comparing them before and after treatment. When we segregated our population according to pathologic complete response, there was no difference in ADC measurements, volumetric measurements or either variability between good (8 Patients) and poor responders (7 Patients). When comparing the before-after changes in our measurement between the Ewing sarcoma and Osteosarcoma cases, there was no significant difference in the change between pre and post treatment (Δ) Mean or Maximum ADC, or in Δtumor-volume when measured on STIR or SPIR T1 post-contrast sequences. Only the ΔMinimum-ADC showed a statistically significant difference (p < 0.02) in this group | ||
| 520 | |a CONCLUSIONS: ADC can potentially reflect cellular changes associated with chemotherapy use, reflecting a response to treatment. However, quantitative use of those parameters to dictate a change in management, treatment regimen or chemotherapy dose in order to target a good response (>/ = 90 % necrosis post-excision) needs further investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Apparent Diffusion Coefficient (ADC) | |
| 650 | 4 | |a Diffusion Weighted Imaging (DWI) | |
| 650 | 4 | |a Ewing sarcoma | |
| 650 | 4 | |a Magnetic Resonance Imaging (MRI) | |
| 650 | 4 | |a Osteosarcoma | |
| 650 | 4 | |a Post-treatment | |
| 700 | 1 | |a Saade, Charbel |e verfasserin |4 aut | |
| 700 | 1 | |a Salman, Rida |e verfasserin |4 aut | |
| 700 | 1 | |a Saab, Raya |e verfasserin |4 aut | |
| 700 | 1 | |a Khoury, Nabil J |e verfasserin |4 aut | |
| 700 | 1 | |a Abboud, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Tamim, Hani |e verfasserin |4 aut | |
| 700 | 1 | |a Makki, Maha |e verfasserin |4 aut | |
| 700 | 1 | |a Naffaa, Lena |e verfasserin |4 aut | |
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