Overexpression of particularly interesting new cys-his rich protein (PINCH) is a risk factor for growth of unruptured intracranial aneurysms
IJCEP Copyright © 2018..
Particularly interesting new cys-his rich protein (PINCH), as an adaptor protein, regulates matrix deposition, cell proliferation, invasion, and metastasis. PINCH plays an important role for tumorigenesis and progression. However, the contributions of PINCH to intracranial aneurysms (IA) remain largely unknown. In our study, we demonstrated that PINCH expression was significantly increased in IA samples compared with healthy controls. The size of IA had a remarkable correlation with PINCH expression. However, PINCH expression had no obvious difference among different Hunt-Hess grades. In addition, the expressions of MMP-2 and MMP-9 were significantly increased in IA tissues compared with healthy controls; moreover, PINCH expression in IA tissues was significantly correlated with MMP-2 and MMP-9 expression. In conclusion, these results suggest that PINCH might play a role similar to MMP-2 and MMP-9 in the pathogenesis of IA. PINCH might be a risk factor for growth of unruptured IA, and this might be a target for diagnosis and therapy of IA.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2018 |
---|---|
Erschienen: |
2018 |
Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
---|---|
Enthalten in: |
International journal of clinical and experimental pathology - 11(2018), 5 vom: 15., Seite 2636-2641 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Li, Wei [VerfasserIn] |
---|
Themen: |
Intracranial aneurysms |
---|
Anmerkungen: |
Date Revised 19.01.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
NLM305369261 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM305369261 | ||
003 | DE-627 | ||
005 | 20231225121027.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2018 xx |||||o 00| ||eng c | ||
028 | 5 | 2 | |a pubmed24n1017.xml |
035 | |a (DE-627)NLM305369261 | ||
035 | |a (NLM)31938378 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Li, Wei |e verfasserin |4 aut | |
245 | 1 | 0 | |a Overexpression of particularly interesting new cys-his rich protein (PINCH) is a risk factor for growth of unruptured intracranial aneurysms |
264 | 1 | |c 2018 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 19.01.2020 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a IJCEP Copyright © 2018. | ||
520 | |a Particularly interesting new cys-his rich protein (PINCH), as an adaptor protein, regulates matrix deposition, cell proliferation, invasion, and metastasis. PINCH plays an important role for tumorigenesis and progression. However, the contributions of PINCH to intracranial aneurysms (IA) remain largely unknown. In our study, we demonstrated that PINCH expression was significantly increased in IA samples compared with healthy controls. The size of IA had a remarkable correlation with PINCH expression. However, PINCH expression had no obvious difference among different Hunt-Hess grades. In addition, the expressions of MMP-2 and MMP-9 were significantly increased in IA tissues compared with healthy controls; moreover, PINCH expression in IA tissues was significantly correlated with MMP-2 and MMP-9 expression. In conclusion, these results suggest that PINCH might play a role similar to MMP-2 and MMP-9 in the pathogenesis of IA. PINCH might be a risk factor for growth of unruptured IA, and this might be a target for diagnosis and therapy of IA | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a MMP-2 | |
650 | 4 | |a MMP-9 | |
650 | 4 | |a Particularly interesting new cys-his rich protein | |
650 | 4 | |a intracranial aneurysms | |
650 | 4 | |a prognosis | |
700 | 1 | |a Ma, Lin |e verfasserin |4 aut | |
700 | 1 | |a Tian, Chao |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t International journal of clinical and experimental pathology |d 2008 |g 11(2018), 5 vom: 15., Seite 2636-2641 |w (DE-627)NLM182361349 |x 1936-2625 |7 nnns |
773 | 1 | 8 | |g volume:11 |g year:2018 |g number:5 |g day:15 |g pages:2636-2641 |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 11 |j 2018 |e 5 |b 15 |h 2636-2641 |