Overexpression of particularly interesting new cys-his rich protein (PINCH) is a risk factor for growth of unruptured intracranial aneurysms

IJCEP Copyright © 2018..

Particularly interesting new cys-his rich protein (PINCH), as an adaptor protein, regulates matrix deposition, cell proliferation, invasion, and metastasis. PINCH plays an important role for tumorigenesis and progression. However, the contributions of PINCH to intracranial aneurysms (IA) remain largely unknown. In our study, we demonstrated that PINCH expression was significantly increased in IA samples compared with healthy controls. The size of IA had a remarkable correlation with PINCH expression. However, PINCH expression had no obvious difference among different Hunt-Hess grades. In addition, the expressions of MMP-2 and MMP-9 were significantly increased in IA tissues compared with healthy controls; moreover, PINCH expression in IA tissues was significantly correlated with MMP-2 and MMP-9 expression. In conclusion, these results suggest that PINCH might play a role similar to MMP-2 and MMP-9 in the pathogenesis of IA. PINCH might be a risk factor for growth of unruptured IA, and this might be a target for diagnosis and therapy of IA.

Medienart:

E-Artikel

Erscheinungsjahr:

2018

Erschienen:

2018

Enthalten in:

Zur Gesamtaufnahme - volume:11

Enthalten in:

International journal of clinical and experimental pathology - 11(2018), 5 vom: 15., Seite 2636-2641

Sprache:

Englisch

Beteiligte Personen:

Li, Wei [VerfasserIn]
Ma, Lin [VerfasserIn]
Tian, Chao [VerfasserIn]

Themen:

Intracranial aneurysms
Journal Article
MMP-2
MMP-9
Particularly interesting new cys-his rich protein
Prognosis

Anmerkungen:

Date Revised 19.01.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM305369261