Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10

Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently available. KREMEN1 (KRM1) is the entry receptor for the largest receptor-group of hand-foot-and-mouth disease causing viruses, which includes CV-A10. We report here structures of CV-A10 mature virus alone and in complex with KRM1 as well as of the CV-A10 A-particle. The receptor spans the viral canyon with a large footprint on the virus surface. The footprint has some overlap with that seen for the neonatal Fc receptor complexed with enterovirus E6 but is larger and distinct from that of another enterovirus receptor SCARB2. Reduced occupancy of a particle-stabilising pocket factor in the complexed virus and the presence of both unbound and expanded virus particles suggests receptor binding initiates a cascade of conformational changes that produces expanded particles primed for viral uncoating.

Medienart:

E-Artikel

Erscheinungsjahr:

2020

Erschienen:

2020

Enthalten in:

Zur Gesamtaufnahme - volume:11

Enthalten in:

Nature communications - 11(2020), 1 vom: 07. Jan., Seite 38

Sprache:

Englisch

Beteiligte Personen:

Zhao, Yuguang [VerfasserIn]
Zhou, Daming [VerfasserIn]
Ni, Tao [VerfasserIn]
Karia, Dimple [VerfasserIn]
Kotecha, Abhay [VerfasserIn]
Wang, Xiangxi [VerfasserIn]
Rao, Zihe [VerfasserIn]
Jones, E Yvonne [VerfasserIn]
Fry, Elizabeth E [VerfasserIn]
Ren, Jingshan [VerfasserIn]
Stuart, David I [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
KREMEN1 protein, human
Membrane Proteins
Receptors, Virus
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 20.04.2020

Date Revised 20.03.2024

published: Electronic

Citation Status MEDLINE

doi:

10.1038/s41467-019-13936-2

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM305110055